Topic
X chromosome
About: X chromosome is a research topic. Over the lifetime, 9862 publications have been published within this topic receiving 407354 citations. The topic is also known as: GO:0000805 & chrX.
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TL;DR: This review discusses recent progress that has put the goal of identifying the factors that interact with Xist RNA to initiate heritable gene silencing in sight.
155 citations
TL;DR: Analysis of XCI in tetraploid XXXX, XXXY, and XXYY embryonic stem cells found that every X chromosome within a single nucleus has an independent probability to initiate XCI, suggesting a stochastic mechanism directing XCI counting and choice.
154 citations
154 citations
Journal Article•
TL;DR: The combination of rearrangement in 14q32 and monosomy X and that of trisomy 3 and deletion in 6q21 occurred only in the acute or lymphoma type and may be associated with the aggressiveness in adult T-cell leukemia/lymphoma.
Abstract: Karyotypes of 107 cases with adult T-cell leukemia/lymphoma (58 male, 49 female; 81 acute or lymphoma type, 26 chronic or smoldering type) were reviewed by a panel of cytogeneticists and were correlated with the subtypes of the disease. Clonal chromosome abnormalities were found in 103 (96%) cases, of which four had hypotetraploidy. Of 184 numerical abnormalities in the remaining 99 cases with near- or pseudodiploidy, trisomies for chromosomes 3 (21% of cases), 7 (10%), and 21 (9%), monosomy for X chromosome (38%) in the female, and loss of a Y chromosome (17%) in the male were more frequent than expected (P or
154 citations
TL;DR: It is proposed that the wild-type xol-1 gene product promotes male development by ensuring that genes (or gene products) directing hermaphrodite sex determination and dosage compensation are inactive in XO animals.
154 citations