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X chromosome

About: X chromosome is a research topic. Over the lifetime, 9862 publications have been published within this topic receiving 407354 citations. The topic is also known as: GO:0000805 & chrX.


Papers
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Journal ArticleDOI
16 Aug 2013-Science
TL;DR: In this article, the authors investigated the localization mechanisms of the Xist lncRNA during X-chromosome inactivation (XCI), a paradigm of lncRN-mediated chromatin regulation.
Abstract: Many large noncoding RNAs (lncRNAs) regulate chromatin, but the mechanisms by which they localize to genomic targets remain unexplored. We investigated the localization mechanisms of the Xist lncRNA during X-chromosome inactivation (XCI), a paradigm of lncRNA-mediated chromatin regulation. During the maintenance of XCI, Xist binds broadly across the X chromosome. During initiation of XCI, Xist initially transfers to distal regions across the X chromosome that are not defined by specific sequences. Instead, Xist identifies these regions by exploiting the three-dimensional conformation of the X chromosome. Xist requires its silencing domain to spread across actively transcribed regions and thereby access the entire chromosome. These findings suggest a model in which Xist coats the X chromosome by searching in three dimensions, modifying chromosome structure, and spreading to newly accessible locations.

875 citations

Journal ArticleDOI
29 Jan 1993-Cell
TL;DR: It is reported that patients with hyper-IgM syndrome (HIM) have a defective gp39-CD40 interaction, which suggests that a defect in gp39 is the basis of X-linked HIM.

840 citations

Journal ArticleDOI
05 May 2016-Cell
TL;DR: A comprehensive transcriptional map of human embryo development, including the sequenced transcriptomes of 1,529 individual cells from 88 human preimplantation embryos, shows that cells undergo an intermediate state of co-expression of lineage-specific genes, followed by a concurrent establishment of the trophectoderm, epiblast, and primitive endoderm lineages, which coincide with blastocyst formation.

827 citations

Journal ArticleDOI
24 Dec 1987-Cell
TL;DR: The possibility that the Y-encoded finger protein is the testis-determining factor is discussed, and models of sex determination accommodating the finding of a related locus on the X chromosome are proposed.

811 citations

Journal ArticleDOI
TL;DR: Results suggest that X chromosome abnormalities contribute to the pathogenesis of BLC, both inherited and sporadic.

808 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202372
2022124
2021192
2020179
2019190
2018186