Xanthene

About: Xanthene is a research topic. Over the lifetime, 2132 publications have been published within this topic receiving 34803 citations. The topic is also known as: Xanthene & dibenzo[a,e]pyran.

ChCl: Gly (DESs) Promote Environmentally Benign Synthesis of Xanthene Derivatives and Their Antitubercular Activity

Abstract: A ChCl: Gly (DESs) promoted environmentally benign method was developed for the first time using the reaction of aryl aldehydes and dimedone to give excellent yields of xanthene analogues. The major application of this present protocol is the use of green solvent, a wide range of substrate, short reaction times, ease of recovery, the recyclability of the catalyst, high reaction yield, and ChCl: Gly as an alternative catalyst and solvent. In addition to this, all the synthesized compounds were evaluated for their in vitro antimycobacterial activity against M. tuberculosis H37Ra (MTB) and M. bovis BCG strains. The compounds 3d, 3e, 3f, and 3j showed significant antitubercular activity against MTB and M. bovis strains with minimum inhibitory concentration (MIC) values of 2.5−15.10 µg/mL and 0.26–14.92 µg/mL, respectively. The compounds 3e, 3f, and 3j were found to be nontoxic against MCF-7, A549, HCT 116, and THP-1 cell lines. All the prepared compounds were confirmed by 1H NMR and 13C NMR analysis.

Method for preparing xanthene amerantrone derivative via catalysis of acidic ionic liquid

Abstract: The invention provides a method for preparing a xanthene amerantrone derivative via the catalysis of an acidic ionic liquid, and belongs to the technical field of organic chemosynthesis. The method comprises the following steps: performing a condensation reaction, wherein the molar ratio of aromatic aldehyde to a 1,3 hexanedione derivative is 1:2, the molar weight of an acidic ionic liquid catalyst accounts for 5% to 10% of the adopted aromatic aldehyde and the adding amount of absolute ethyl alcohol serving as a reaction solvent accounts for 70% to 90% of the total weight of materials; performing a reflux reaction for 2 to 5 hours under the action of one atmospheric pressure as the reaction pressure; after reacting, cooling by using ice water and filtering; and recrystallizing filter residues by using 95% of ethanol, thereby obtaining the pure xanthene amerantrone derivative. Compared with the traditional preparation method taking acid, alkali and other acidic ionic liquids as the catalysts, the method provided by the invention has the characteristics of being high in catalytic activity and less in catalyst adding amount, realizing catalyst recycling and the like.

Synthesis of Xanthene Derivatives over Acid Activated Clay in Kerman Province and Kinetic Modeling

Abstract: 14-aryl-14H-dibenzo[a,j]xanthenes are extensively used as dyes, pH-sensitive fluorescent material for visualization of biomolecules, and in laser technologies. The synthesis of aryl-14H-dibenzo[a,j]xanthene derivatives is studied using acid activated clay as reusable eco-friendly catalyst under solvent free condition. The reaction is carried out by hydrochloric acid activated clay. Clay is supplied from Kheirabad mine in Kerman province, Iran. Activation is done by 1, 2, 3, and 5 mol/L HCl. Among these catalysts, clay activated by 3 mol/L HCl was found to be a better catalyst which could be reused without any further chemical treatment eliminating the effluent disposal problems. The procedure offers advantages such as shorter reaction time, excellent yields, inexpensive catalyst, environment-friendly, and reusability of catalyst. The reaction obeys the Eley–Rideal type of mechanism. A theoretical kinetic model was developed for the evaluation of this slurry reaction. The effects of various parameters on t...