Topic
Xanthene
About: Xanthene is a research topic. Over the lifetime, 2132 publications have been published within this topic receiving 34803 citations. The topic is also known as: Xanthene & dibenzo[a,e]pyran.
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11 Dec 2017
3 citations
TL;DR: In this paper , a series of easily accessible (three steps) SWIR xanthene dyes based on a dibenzazepine donor conjugated to thiophene (SCR-1), thienothiophene, or bithiophene was developed for deep tissue SWIR photoacoustic imaging.
Abstract: Shortwave infrared (SWIR) dyes are characterized by their ability to absorb light from 900 to 1400 nm, which is ideal for deep tissue imaging owing to minimized light scattering and interference from endogenous pigments. An approach to access such molecules is to tune the photophysical properties of known near-infrared dyes. Herein, we report the development of a series of easily accessible (three steps) SWIR xanthene dyes based on a dibenzazepine donor conjugated to thiophene (SCR-1), thienothiophene (SCR-2), or bithiophene (SCR-3). We leverage the fact that SCR-1 undergoes a bathochromic shift when aggregated for in vivo studies by developing a ratiometric nanoparticle for NO (rNP-NO), which we employed to successfully visualize pathological levels of nitric oxide in a drug-induced liver injury model via deep tissue SWIR photoacoustic (PA) imaging. Our work demonstrates how easily this dye series can be utilized as a component in nanosensor designs for imaging studies.
3 citations
TL;DR: In this article, a novel protic acidic ionic-liquid catalyst for organic synthesis was introduced, and its catalytic activity was examined for the solvent-free reaction of 2-naphthol with arylaldehydes to provide 14-aryl-14 H -dibenzo[ a, j ]xanthenes.
Abstract: The main aim of this work is introducing a novel protic acidic ionic-liquid catalyst for organic synthesis. Thus, N , N -diethyl- N -sulfoethanaminium methanesulfonate ([Et 3 N-SO 3 H][MeSO 3 ]) was synthesized by the reaction of triethylamine with chlorosulfonic acid, and then with methanesulfonic acid. The structure of this novel protic acidic ionic liquid was identified by FT-IR, 1 H NMR, 13 C NMR and mass spectral data. Its catalytic activity was examined for the solvent-free reaction of 2-naphthol with arylaldehydes to provide 14-aryl-14 H -dibenzo[ a , j ]xanthenes. [Et 3 N-SO 3 H][MeSO 3 ] efficiently catalyzed the reaction, and the products were obtained in high to excellent yields and in short reaction times. KEY WORDS : Protic acidic ionic liquid, N , N -Diethyl- N -sulfoethanaminium methanesulfonate ([Et 3 N-SO 3 H][MeSO 3 ]), 2-Naphthol, Arylaldehyde, 14-Aryl-14 H -dibenzo[ a , j ]xanthene Bull. Chem. Soc. Ethiop. 2019 , 33(1), 69-76 DOI: https://dx.doi.org/10.4314/bcse.v33i1.7
3 citations
TL;DR: Asperversin A represents the first example of a steroid-sterigmatocystin heterodimer and was synthesized in 11 steps in this paper, using a cascade dialdehyde cyclization and a SNAr reaction.
3 citations
Patent•
24 Jul 19513 citations