Topic
Xanthine
About: Xanthine is a research topic. Over the lifetime, 4046 publications have been published within this topic receiving 129820 citations. The topic is also known as: Xanthine.
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TL;DR: In this article, the authors solved crystal structures of R. capsulatus XDH in the presence of its substrates hypoxanthine, xanthine and the inhibitor pterin-6-aldehyde using either the inactive desulfo form of the enzyme or an active site mutant (EB232Q).
44 citations
TL;DR: Conversion of theobromine to caffeine may be slow in cacao leaves, because no caffeine biosynthesis from 14 C-labelled purine bases and nucleosides was observed during 18 h incubations, exogenously supplied.
44 citations
TL;DR: 5-methyl uracil (thymine) was found to be as potent as uric acid in stimulating motility suggesting that a substituent at position-5 of the pyrimidine nucleus is probably essential for this latter function.
44 citations
TL;DR: The hydroxyimino-phenethyl scaffold compounds 17-24 represent an interesting starting point to optimize their pharmacokinetics and pharmacodynamics profiles and were predicted to have good to excellent drug likeness profiles specially compounds 18-20 and 23.
44 citations
TL;DR: Xanthine dehydrogenase has been purified to homogeneity by conventional methods followed by immunoabsorption to monospecific antibodies coupled to Sepharose 6B and electrophoresis reveals a single protein band which also exhibits enzyme activity.
44 citations