Topic
Xanthone
About: Xanthone is a research topic. Over the lifetime, 1639 publications have been published within this topic receiving 25870 citations. The topic is also known as: 9-oxo-xanthene & Diphenyline ketone oxide.
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TL;DR: Fluorescence microscopy analysis confirmed that a phagocytic process was involved in the macrophage uptake of xanthone- and 3-methoxyxanth one-loaded PLGA nanocapsules, which might be the main mechanism responsible for the enhancement of the intracellular delivery of both compounds and consequently for the improvement of their biological effect.
Abstract: For the first time the inhibitory effect of xanthone and 3-methoxyxanthone on nitric oxide (NO) production by IFN-gamma/LPS activated J774 macrophage cell line is reported A remarkable improvement of this effect promoted by encapsulation of these compounds in nanocapsules of poly (DL-lactide-co-glycolide) (PLGA) is also demonstrated A weak inhibitory effect of 36% on NO production by activated macrophages was observed for xanthone at the highest studied concentration (100 microM) This effect was slightly higher for 3-methoxyxanthone at the same concentration, producing a reduction of 165% on NO production In contrast, equivalent concentrations of xanthone and 3-methoxyxanthone incorporated in nanocapsules produced a significant decrease on NO production of 918 and 800%, respectively Empty nanocapsules also exhibited a slight NO inhibitory activity, which may be due to the presence of soybean lecithin in the composition of the nanosystems The viability of the macrophages was not affected either by free or nanoencapsulated xanthones Fluorescence microscopy analysis confirmed that a phagocytic process was involved in the macrophage uptake of xanthone- and 3-methoxyxanthone-loaded PLGA nanocapsules Phagocytosis might be the main mechanism responsible for the enhancement of the intracellular delivery of both compounds and consequently for the improvement of their biological effect
19 citations
TL;DR: A new xanthone named paxanthonin, 1,2,6-trihydroxy-8-methoxy-2-(2′,2′-dimethyl-4′-isopropenyl)-cyclopentanyl-xanthone, has been isolated from the callus tissues of Hypericum patulum together with morusignin D as mentioned in this paper.
19 citations
TL;DR: In this paper, a new xanthone diglucoside (1) was isolated from the aerial parts of Swertia perennisL. (Gentianaceae) by means of column chromatography on polyamide, followed by preparative TLC.
Abstract: A new xanthone diglucoside (1) has been isolated from the aerial parts of Swertia perennisL. (Gentianaceae) by means of column chromatography on polyamide, followed by preparative TLC. on silica gel. From UV. and NMR. data, its structure has been established as 1,3-di-β-D-glucopyranosyl-7,8-dihydroxyxanthone or norswertianine-1,3-diglucoside.
19 citations
TL;DR: The mangrove-derived endophytic fungus Peniophora incarnata Z4 produced seven new xanthone derivatives, including four new tetrahydroxanthones (1-4), one new chromone (5), onenew xanth one (6), and one newxanthone dimer (7), together with one known compound, globosuxanthone B (8).
Abstract: The mangrove-derived endophytic fungus Peniophora incarnata Z4 produced seven new xanthone derivatives, including four new tetrahydroxanthones (1-4), one new chromone (5), one new xanthone (6), and one new xanthone dimer (7), together with one known compound, globosuxanthone B (8). Their structures were determined by an extensive analysis of 1D and 2D NMR, HRESIMS, ECD, and single-crystal X-ray diffraction data. In cytotoxic activity assays, compound 2 showed cytotoxicity against three carcinoma cell lines with IC50 values less than 10 μM.
19 citations
TL;DR: In this article, a new strategy based on carbonylation of aryl triflates was developed to prepare 7-methyl rhein from emodin and new xanthone analogs of Rhein.
19 citations