Topic
Xanthone
About: Xanthone is a research topic. Over the lifetime, 1639 publications have been published within this topic receiving 25870 citations. The topic is also known as: 9-oxo-xanthene & Diphenyline ketone oxide.
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TL;DR: The methanol extract and pure compounds were tested on two strains of Plasmodium falciparum, F32 ( chloroquine sensitive) and FcM29 (chloroquine resistant) and the IC50 values obtained ranged from 0.6 to 8.9 microg/ml.
Abstract: Further study of the methanol extract of the stem bark of Allanblackia monticola STANER L.C. resulted in the isolation of a new prenylated xanthenedione, designated allanxanthone C, together with the five known xanthones, garciniafuran, tovophyllin A, rubraxanthone, norcowanin and mangostin and one saponin, stigmasterol-3-O-beta-D-glucopyranoside. The structure of the new compound was established by detailed spectroscopic analysis to be 1,2-dihydro-3,6,8-trihydroxy-1,1,7-tri(3-methylbut-2-enyl)xanthen-2,9-dione (3-hydroxyapetalinone C). The methanol extract and pure compounds were tested on two strains of Plasmodium falciparum, F32 (chloroquine sensitive) and FcM29 (chloroquine resistant). The IC50 values obtained ranged from 0.6 to 8.9 microg/ml. Their cytotoxicity was estimated on human melanoma cells (A375) and the cytotoxicity/antiplasmodial ratio was found to be between 15.45 and 30.46. The antimicrobial activities against a range of microorganisms of the crude extract and some of these compounds are also reported.
75 citations
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TL;DR: In this paper, the 13 C NMR chemical shifts of eleven hydroxy-, two hydroxymethoxy xanthones, and xanthone- C -glucoside, mangiferin, are presented and analyzed.
73 citations
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TL;DR: A xanthone derivative, named gaboxanthone (1), has been isolated from the seed shells of Symphonia globulifera and showed a potent free radical scavenging activity compared to the well-known antioxidant caffeic acid.
73 citations
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TL;DR: All the crude extracts when screened for their larvicidal activities indicated very good toxicity against the larvae of Aedes aegypti.
73 citations
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TL;DR: The here described HPLC-method enables the determination of all major, currently known bioactive compounds in gentian roots and analysis of several commercially available G. lutea samples showed that gentiopicroside is the most dominant compound in the specimens.
72 citations