Topic
Xanthone
About: Xanthone is a research topic. Over the lifetime, 1639 publications have been published within this topic receiving 25870 citations. The topic is also known as: 9-oxo-xanthene & Diphenyline ketone oxide.
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TL;DR: A new prenylated xanthone, 1,3,6-trihydroxy-2-(3-methylbut-2-enyl)-8-formyloxy-3- methylbutyl)–xanthone has been isolated from the pericarp of Garcinia mangostana, together with five known compounds.
Abstract: Mangostanate, a new prenylated xanthone, 1,3,6-trihydroxy-2-(3-methylbut-2-enyl)-8-(3-formyloxy-3-methylbutyl)–xanthone, has been isolated from the pericarp of Garcinia mangostana, together with fi...
17 citations
TL;DR: Phytochemical investigation of a chloroform‐soluble fraction of the freeze‐dried fruits of Garcinia mangostana with anticomplement activity in the classical pathway led to the identification of five known xanthones, confirmed by interpretation of NMR and MS spectroscopic data.
Abstract: Phytochemical investigation of a chloroform-soluble fraction of the freeze-dried fruits of Garcinia mangostana (Clusiaceace) with anticomplement activity in the classical pathway led to the identification of five known xanthones. The structures of these compounds were confirmed by interpretation of NMR and MS spectroscopic data. Of the isolates obtained, 1-isomangostin and garcinone E were found to be active constituents in the anticomplement assay used.
17 citations
Journal Article•
TL;DR: In this article, the physicochemical properties of alkanolamine derivatives of xanthone were described and synthesized by of the reaction of an appropriate aminoalcohol with corresponding 2-bromomethylxanthones.
Abstract: Synthesis and physicochemical properties of alkanolamine derivatives of xanthone are described. Alkanolamines were synthesized by of the reaction of an appropriate aminoalcohol with corresponding 2-bromomethylxanthones. The obtained compounds 1-13 were evaluated for anticonvulsant activity in the maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole seizure threshold (scMet) assays and for neurotoxicity (TOX). Several alkanolamines were found to be active in both the anticonvulsant tests. Most interesting were the 2-amino-1-propanol-, 1-amino-2-propanol- or 1-amino-2-butanol derivatives of 6-methoxy- or 6-chloroxanthone, which displayed anti MES activity with a protective index (TD50/ED50) in the range 2.21-5.84 corresponding with that for phenytoin, carbamazepine and valproate.
17 citations
TL;DR: In this paper, a bioguided separation on the cultures of the potato endophytic fungus Bipolaris eleusines led to the isolation of two anti-phytopathogenic (Alternaria solani) sesquiterpenoid-xanthone adducts, namely bipolins I and J.
Abstract: A bioguided separation on the cultures of the potato endophytic fungus Bipolaris eleusines led to the isolation of two anti-phytopathogenic (Alternaria solani) sesquiterpenoid-xanthone adducts, namely bipolins I and J (1 and 2). Their structures were established via extensive spectroscopic analysis. Compounds 1 and 2 exhibit potent inhibitory activity against A. solani with MIC values of 8 and 16 μg mL−1, respectively.
17 citations
TL;DR: In this paper, the effect of the microenvironment of the host adsorbent on the electronic excited states of the guest molecules included in the restricted void spaces was investigated, and it was shown that xanthone molecules are stabilized in zeolite cavities by the diret interaction between the molecules and the alkali cations anchored in the cavity.
Abstract: The phosphorescence properties of xanthone included in alkali-cation-exchanged zeolites have been investigated to determine the effect of the microenvironment of the host adsorbent on the electronic excited states of the guest molecules included in the restricted void spaces. An enhancement of the phosphorescence yield is observed on changing the exchangeable alkali cation from Li + to Cs + . Simultaneously, the phosphorescence lifetimes are continuously reduced by changing the cation from Li + to Cs + . IR investigation of xanthone included in alkali-cation-exchanged Y-zeolite shows that xanthone molecules are stabilized in zeolite cavities by the diret interaction between the molecules and the alkali cations anchored in the cavity. These results are well explained in terms of the external heavy-atom effect, derived from the alkali cations Li + , Na + , K + , Rb + and Cs + , on the singlet-triplet transitions of xanthone molecules included in the alkali-cation-exchanged zeolites.
16 citations