Topic
Xanthone
About: Xanthone is a research topic. Over the lifetime, 1639 publications have been published within this topic receiving 25870 citations. The topic is also known as: 9-oxo-xanthene & Diphenyline ketone oxide.
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TL;DR: Two prenylated xanthones, 1,4,5,6,tetrahydroxy-2-(1,1-dimethyl-2-propenyl)-7,8-di-(3-methyl-2 -butenyl)xanthone (subelliptenone A) and 1,2,5.6,6-tetrahedroxy-4-(1 1,1]-dimethyl 2-pro-penyl]-7-(3]-methyl 2 butenyl (3)-methyl 2-buten
16 citations
TL;DR: Two new xanthone glucosides, 2,3,7-trimethoxyxanthone-1- O -glucoside and 2, 3,5-tricyclic Xanthone 1-Oglucose, were isolated from the whole plant of Halenia elliptica and identified through their acetates as mentioned in this paper.
16 citations
TL;DR: Among them, compounds 1 and 2, the most potent and major constituents of G. mangostana, inhibited HSC-T6 viability in dose- and time-dependent manners and significantly reduced collagen content, a pathological characteristic of liver fibrosis.
Abstract: From the CHCl3-soluble fraction of the fruits of Garcinia mangostana (Clusiaceae), six xanthone derivatives, alpha-mangostin (1), gamma-mangostin (2), gartanin (3), deoxygartanin (4), 1-isomangstanin (5) and garcinone E (6), were isolated. All these compounds significantly inhibited HSC-T6 viability as assessed by employing HSC-T6 hepatic stellate cells as an in vitro assay system. Among them, compounds 1 and 2, the most potent and major constituents of G. mangostana, inhibited HSC-T6 viability in dose- and time-dependent manners. In addition, compounds 1 and 2 significantly reduced collagen content, a pathological characteristic of liver fibrosis. Taken together, G. mangostana and its constituents might be beneficial for the treatment of liver fibrosis.
16 citations
TL;DR: A series of xanthone sulfonamides were synthesized and evaluated to result in the identification of several potent ACAT inhibitors, among which 2n proved to be more potent than the positive control Sandoz58-35.
16 citations
TL;DR: A new furanodihydrobenzoxanthone, artomandin, together with three other flavonoid derivatives, artoindonesianin C, artonol B, and artochamin A, as well as β-sitosterol, were isolated from the stem bark of Artocarpus kemando on the basis of spectral evidence.
16 citations