Topic
Xanthone
About: Xanthone is a research topic. Over the lifetime, 1639 publications have been published within this topic receiving 25870 citations. The topic is also known as: 9-oxo-xanthene & Diphenyline ketone oxide.
Papers published on a yearly basis
Papers
More filters
TL;DR: The structures of the isolates were determined by mass spectrometry and 2D-NMR techniques including HSQC, HMBC, NOESY and 1H-1H COSY experiments and are the first report of their isolation from a Pueraria species.
Abstract: Bioassay-guided fraction of the methanol extract of the roots of Pueraria tuberose DC yielded puerarin, an isoflavone C-glycoside (PT-1), isoorientin, a flavone C-glycoside (PT-2) and mangiferin, a xanthone C-glycoside (PT-3). The extracts and the isolated compounds were screened for potent anti-inflammatory components inhibiting the cyclooxygenases (COX-1 and COX-2) and 5-lipoxygenase (5-LOX), the target enzymes of inflammation, by employing spectroscopic/polorographic methods. Among these, isoorientin was found to be a potent inhibitor of COX-2with an IC50 value of 39 μM. Docking studies were carried out to understand the interactions of isorientin (PT-2) with COX-2.The structures of the isolates were determined by mass spectrometry and 2D-NMR techniques including HSQC, HMBC, NOESY and 1H-1H COSY experiments. Although isoorientin and mangiferin have been reported from several plant sources, this is the first report of their isolation from a Pueraria species.
14 citations
TL;DR: The RM values of a series of xanthone derivaties obtained in a chromatographic system were correlated with the calculated log P values, indicating the importance of lipophilic character in determining the acute toxicity of xAnthone derivatives in mice.
14 citations
TL;DR: Seven new xanthone glycosides were isolated from the n-butanol extract of Swertia bimaculata, together with six known compounds, and compounds 3, 4, and 7 exhibited significant activities to inhibit α-glucosidase.
Abstract: Seven new xanthone glycosides ( 1 – 7 ) were isolated from the n -butanol extract
of Swertia bimaculata , together with six known compounds ( 8 – 13 ). Their
structures were elucidated on the basis of extensive spectroscopic analyses (1D- and 2D-NMR,
HRESIMS, UV, and IR) and comparison with data reported in the literature. All the compounds were
evaluated for their α -glucosidase inhibitory activities in vitro , and compounds
3, 4 , and 7 exhibited significant activities to inhibit α -glucosidase.
Meanwhile the effects of different substitutions on the α -glucosidase inhibitory activity
of xanthone glycosides from S. bimaculata are also discussed.
14 citations
TL;DR: A new stereoisomeric pyrano xanthone together with the previously known fungal metabolites, epiisoshamixanthone, was obtained from the endophytic fungal strain Aspergillus sp.
14 citations
TL;DR: Results suggested that 1‐hydroxy‐3‐[2‐(pyrrolidin‐1‐yl)ethoxy]‐9H‐xanthen‐9‐one was promising AChEI with metal chelating ability and antioxidant ability for the further investigation.
Abstract: Four xanthone derivatives were synthesized and evaluated as acetylcholinesterase inhibitors (AChEIs) with metal chelating ability and antioxidant ability against Alzheimer's disease (AD). Most of them exhibited potential acetylcholinesterase (AChE), butylcholinesterase (BuChE) inhibitory, antioxidant and metal chelating properties. Among them, 1-hydroxy-3-[2-(pyrrolidin-1-yl)ethoxy]-9H-xanthen-9-one had the highest ability to inhibit AChE and displayed high selectivity towards AChE (IC50 =2.403±0.002 μM for AChE and IC50 =31.221±0.002 μM for BuChE), and it was also a good antioxidant (IC50 =2.662±0.003 μM). Enzyme kinetic studies showed that this compound was a mixed-type inhibitor, which could interact simultaneously with the catalytic anionic site (CAS) and the peripheral anionic site (PAS) of AChE. Interestingly, its copper complex showed more significant inhibitory activity for AChE (IC50 =0.934±0.002 μM) and antioxidant activity (IC50 =1.064±0.003 μM). Molecular dockings were carried out for the four xanthone derivatives in order to further investigate the binding modes. Finally, the blood-brain barrier (BBB) penetration prediction indicated that all compounds might penetrate BBB. These results suggested that 1-hydroxy-3-[2-(pyrrolidin-1-yl)ethoxy]-9H-xanthen-9-one was promising AChEI with metal chelating ability and antioxidant ability for the further investigation.
14 citations