Topic
Xanthone
About: Xanthone is a research topic. Over the lifetime, 1639 publications have been published within this topic receiving 25870 citations. The topic is also known as: 9-oxo-xanthene & Diphenyline ketone oxide.
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TL;DR: The 1,3,6,8-tetraoxygenated xanthone structure assigned to a compound from Halenia elliptica is incorrect as discussed by the authors, based on published evidence, the Xanthone appears to be 1-hydroxy-2, 3, 7-trimethoxyxanthone.
8 citations
TL;DR: A total synthesis of an anticancer xanthone natural product termicalcicolanone A utilizing multiple nucleophilic aromatic substitutions and pericyclic reactions has been developed.
8 citations
TL;DR: In this article, prenyl bromide was used to prenylonize 5-methoxy-1, 3-dihydroxyxanthone and 2-C-prenyl derivatives in the presence of methanolic methoxide.
8 citations
TL;DR: In this article, a comminuted herb was extracted exhaustively with hot 70% ethanol, the extract was concentrated and diluted with water (1:2) and was treated successively with petroleum ether (I) with chloroform (II), and with chlorofornr-ethyl acetate (2:1) (III).
Abstract: To isolate the coumarins, the comminuted herb was extracted exhaustively with hot 70% ethanol, the extract was concentrated and diluted with water (1:2) and was treated successively with petroleum ether (I) with chloroform (II), and with chlorofornr-ethyl acetate (2:1) (III) [i]. The combined dry residues II and III were transferred to a column of Woelm polyamide (5 x 20 cm). The fractions eluted by chloroform and chloroform-ethanol (2:1) were rechromatographed on Silufol plates in the benzene-ethyl acetate (2:1) system [2]. Two individual substances were isolated: A with Rf 0.72 and B with Rf 0.36. When the column was washed further with chloroform-acetone (7:3), the fractions contained a substance C with Rf 0.09 [3, 4]. The substances obtained were subjected to repeated recrystallization from methanol.
7 citations
TL;DR: A series of structure-based 3-aryl substituted xanthone derivatives in which diverse functional groups were respectively attached on 3-aromatic ring moiety as new tyrosinase inhibitors were targeted, suggesting that such type of molecules might be utilized for the development of new and promising candidate for the treatment of depigmentation-related disorders.
Abstract: Tyrosinase plays a key role in the melanin biosynthesis since it catalyzes the transformation of tyrosine into L-dopaquinone. A large number of studies have also shown that molecules to efficiently inhibit the activity of tyrosinase would be potentially used in treating many depigmentation-related disorders. In this study, we targeted a series of structure-based 3-aryl substituted xanthone derivatives in which diverse functional groups were respectively attached on 3-aromatic ring moiety as new tyrosinase inhibitors. The results demonstrated that all obtained compounds had potent tyrosinase inhibitory activities with IC50 values at micromolar range. Especially, compound 4t was found to be the most active tyrosinase inhibitor with the IC50 value of 11.3 µM, uncovering that the introduction of the proper hydroxyl group in the 3-aromatic ring was beneficial for enhancing the inhibitory potency against tyrosinase. Moreover, the inhibition mechanism and inhibition kinetics studies revealed that compound 4t presented such inhibitory effect by acting as the reversible and competitive-uncompetitive mixed-II type inhibitor. Further molecular docking simulation showed that 3-aromatic ring of compound 4t was inserted into the narrow regions of binuclear copper-binding site at the bottom of the enzyme binding pocket, while the xanthone skeleton was positioned at the surface of tyrosinase. Taken together, these data suggested that such type of molecules might be utilized for the development of new and promising candidate for the treatment of depigmentation-related disorders.
7 citations