Topic
Xanthone
About: Xanthone is a research topic. Over the lifetime, 1639 publications have been published within this topic receiving 25870 citations. The topic is also known as: 9-oxo-xanthene & Diphenyline ketone oxide.
Papers published on a yearly basis
Papers
More filters
6 citations
TL;DR: The structures of 12 known compounds in Cratoxylum cochinchinense stem bark were elucidated on the basis of spectroscopic methods, including UV, IR, NMR and MS.
Abstract: Chemical investigation of Cratoxylum cochinchinense stem bark has led to the isolation and identification of a new xanthone, cochinchinone M (1), together with 12 known compounds. Their structures were elucidated on the basis of spectroscopic methods, including UV, IR, NMR and MS. Some compounds were evaluated for their antibacterial and acetylcholinesterase inhibitory activities.
6 citations
TL;DR: In this article, a spray-drying of xanthone with oil emulsion using inulin as the wall material was used to improve the aqueous solubility of Xanthone-containing microcapsules.
Abstract: The objective of this work was to produce xanthone-containing microcapsules by spray drying xanthone with oil emulsion using inulin as the wall material. Inlet air temperature of 200C resulted in free-flowing powder and encapsulation yield was remained at 65% at core-to-wall ratios of 1:2, 1:4 and 1:6. The solubility of xanthone-containing microcapsules was greatly improved to 120.1 ± 2.9 μg/mL compared to that of free xanthone. Physical stability and xanthone retention of microcapsules decreased with increasing storage relative humidity (RH) from 33 to 75%, as supported by the decreasing of glass transition temperature (Tg). Fourier transform infrared spectroscopy (FTIR) confirmed the encapsulation of xanthone within the inulin matrix. Xanthone showed an obvious burst release in simulated intestinal fluid compared to that of simulated gastric fluid. Xanthone microcapsules are useful for functional food product development.
Practical Applications
Xanthone is well-known for its anti-oxidant, anti-carcinogenic and anti-inflammatory properties. However, its application in food and pharmaceutical products is limited due to its poor aqueous solubility. The current work is significant to improve the aqueous solubility of xanthone and to protect xanthone from external environment through spray drying. The improved aqueous solubility of xanthone microcapsules is useful for functional food product development.
6 citations
TL;DR: The structures of three standard samples commercially available as polygalaxanthone III were characterized by LC/MS and NMR and revealed that two molecular types exist, which are chromatographically separable but have an identical mass number with distinguishable MS/MS spectra.
Abstract: Polygalaxanthone III, a xanthone glycoside that is a major constituent of "Polygala Root" (Polygala tenuifolia roots, Onji in the Japanese Pharmacopoeia), has been used as a standard in the quality control of crude drugs. However, we previously noted differences in the chromatographic properties of one of three samples of polygalaxanthone III. Therefore, standardization of the standard itself is extremely important. The structures of three standard samples commercially available as polygalaxanthone III were characterized by LC/MS and NMR. LC/MS analysis revealed that two molecular types exist. Both types are chromatographically separable but have an identical mass number with distinguishable MS/MS spectra. One dimensional (1D)-NMR analyses demonstrated that both had the same xanthone moiety and heteronuclear multiple bond correlation (HMBC) analyses revealed that they are structural isomers at the connecting position of glucose to apiose 1-position. Consequently, the isomers were identified as polygalaxanthone III and its regioisomer, polygalaxanthone XI. Based on the findings, we recommend using the LC-MS/MS detection method, which discriminates polygalaxanthone III and XI, to confirm the quality of the standard.
6 citations
TL;DR: A new xanthone, clusone, isolated from the fresh flowers of an Amazonian medicinal plant, Clusia insignis, has been characterized as 1-3,4,5,6-pentamethoxy 9H-xanthen-9-one by means of spectroscopic evidence.
6 citations