Topic
Xanthone
About: Xanthone is a research topic. Over the lifetime, 1639 publications have been published within this topic receiving 25870 citations. The topic is also known as: 9-oxo-xanthene & Diphenyline ketone oxide.
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TL;DR: In this article, a new dihydrochromene derivative, named lisofurvin (1) and a xanthone, named diHydrobrasixanthone B (2) together with twenty one known compounds (3−23) were isolated from propolis of the stingless bee Lisotrigona furva.
6 citations
6 citations
TL;DR: Five new xanthone glycosides, comastomasides A-E (1-5), were isolated from aqueous ethanol extracts of the aerial portions of Comastoma pedunculatum by spectroscopic analysis methods, and exhibited potent hepatoprotective activity and cytotoxicity against four human cancer cell lines by in vitro assays.
Abstract: Five new xanthone glycosides, comastomasides A-E (1-5), were isolated from aqueous ethanol extracts of the aerial portions of Comastoma pedunculatum. The structures of these compounds were elucidated by spectroscopic analysis methods. Compounds 1-5 were evaluated for their hepatoprotective activity and cytotoxicity against four human cancer cell lines by in vitro assays. Among them, compounds 3 and 5 exhibited potent hepatoprotective activity. However, none of the compounds displayed cytotoxic activity.
6 citations
01 Jan 2015
TL;DR: Mangosteen rind after investigation it turned out to contain several compounds with pharmacological activities such anti-aging as discussed by the authors, such as anti-oxidants, prevent osteoporosis, antiviral, antidiabetic, antipyretics, antidepressants, anti-inflammatory, antihistamine, treatment of heart disease, antibacterial, antifungal even for the treatment or therapy of HIV disease.
Abstract: Mangosteen rind after investigation it turned out to contain several compounds with pharmacological activities such anti-aging. Anti-oxidants, prevent osteoporosis, antiviral, antidiabetic, antipyretics, antidepressants, anti-inflammatory, antihistamine, treatment of heart disease, antibacterial, antifungal even for the treatment or therapy of HIV disease. Some of the main compound content of the mangosteen rind reportedly responsible for some of the pharmacological activity of a class of xanthones. Chemical Ingredients mangosteen rind is xanthones, which is a naturally occurring chemical substances classified as flavonoids. These compounds are commonly found in plants that are red, purple, blue, or yellow. Classification is oxygenated xanthones xanthones, xanthone glycoside, prenylanted xanthones, xanthonolignoid, and miscellaneous xanthones. Xanthone content of the most important being the Alpha-mangostin. Alpha-mangostin compounds suppress the formation of carcinogenic compounds with demonstrated anti-proliferative activity and apoptosis terpoten among other xanthone compounds. This compound is able to activate the apoptotic enzyme caspase-3 and - 9, but not in caspase-8. Alpha mangostin allegedly mediated mitochondrial apoptosis pathway. Keyword : anticancer, apoptosis,mangosteen, xanthone Abstrak Kulit buah manggis setelah diteliti ternyata mengandung beberapa senyawa dengan aktivitas farmakologi misalnya anti-aging. Anti-oksidan, mencegah osteoporosis, antivirus, antidiabetes, antipiretik, antidepresan, antiinflamasi, antihistamin, pengobatan penyakit jantung, antibakteri, antijamur bahkan untuk pengobatan atau terapi penyakit HIV. Beberapa senyawa utama kandungan kulit buah manggis yang dilaporkan bertanggung jawab atas beberapa aktivitas farmakologi adalah golongan xanton. Kandungan kimia kulit buah manggis adalah xanton, yang merupakan substansi kimia alami yang tergolong senyawa flavonoid. Senyawa ini umumnya ditemukan pada tumbuhan yang berwarna merah, ungu, biru, atau kuning. Klasifikasi xanton yaitu oxygenated xanthone, xanthone glycoside, prenylanted xanthone, xanthonolignoid, dan miscellaneous xanthone. Kandungan dalam xanton yang terpenting yaitu Alfa-mangostin. Senyawa Alfa-mangostin menekan pembentukan senyawa karsinogen dengan menunjukkan aktivitas anti-proliferasi dan apoptosis terpoten diantara senyawa xanton lainnya. Senyawa tersebut mampu mengaktivasi enzim apoptosis caspase-3 dan - 9, namun tidak pada caspase-8. Alfa-mangostin diduga kuat mem-perantarai apoptosis jalur mitokondria. Kata kunci : antikanker,apoptosis, manggis, xanton
6 citations
Patent•
16 Feb 2018
TL;DR: An xanthone compound substituted by 2,4-difluorophenyl is disclosed in this paper, where the structure of the compound is shown as a following formula.
Abstract: An xanthone compound substituted by 2,4-difluorophenyl is disclosed The compound is 7-(2,4-difluorophenyl)-1,3-dihydroxyl xanthone The structure of the compound is shown as a following formula The7-(2,4-difluorophenyl)-1,3-dihydroxyl xanthone is a novel xanthone compound, has obvious antitumor activity and tyrosinase inhibiting activity, and can be used for preparing antitumor medicines, and medicines, healthcare products, foods and cosmetics in the field of tyrosinase regulation A preparing method of the xanthone compound is simple to operate, reaction conditions are mild, the yield is high and the method can be used for large-scale preparation of the 7-(2,4-difluorophenyl)-1,3-dihydroxyl xanthone
6 citations