Topic
Xanthone
About: Xanthone is a research topic. Over the lifetime, 1639 publications have been published within this topic receiving 25870 citations. The topic is also known as: 9-oxo-xanthene & Diphenyline ketone oxide.
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31 Oct 2013
TL;DR: A chemometrical approach was useful to establish a pattern of antitubercular activity among the group of ω-aminoalkoxylxanthones, according to some structural and chemical features.
Abstract: A new dihydropyranexanthone derived from the natural xanthone lichexanthone (1) was synthesised and, together with other 18 derivatives including ω-bromo and ω-aminoalkoxylxanthones (containing methyl, ethyl, propyl, tertbutylamino and piperidinyl moieties), were tested against Mycobacterium tuberculosis. Nine ω-aminoalkoxylxanthones showed good antimycobacterial activity, and their in vitro cytotoxicity was determined using VERO cells in order to calculate the selectivity index (SI). One of these nitrogenated xanthone derivatives showed very promising results, with MIC of 2.6 μM and SI of 48. This MIC is comparable to values found in “first and second line” drugs commonly used to treat TB. In order to understand better about this compound, it was evaluated together with two other ones that showed good SI, against resistant clinical strains of M. tuberculosis to verify the existence of cross-resistance. A chemometrical approach was useful to establish a pattern of antitubercular activity among the group of ω-aminoalkoxylxanthones, according to some structural and chemical features.
5 citations
5 citations
Journal Article•
TL;DR: The topical anti-inflammatory activity of all isolated compounds and extracts was investigated employing the croton oil-induced dermatitis in mouse ear and the most active compound, luteolin, showed an ID50 of 0.3 μmol/cm2 and prevented ear oedema more effectively than an equimolar dose of indomethacin within 24 h.
Abstract: Bioactivity-guided fractionation of the methanol extract from the leaves of Santolina insularis led to the isolation of one new xanthone, (E)-3-{6-[(E)-3-hydroxy-3-oxo-1-propenyl]-9- oxo-9H-xanthen-2-yl}-2-propenoic acid, together with six known flavonoids: hispidulin, nepetin, cirsimaritin, rhamnocitrin, luteolin and luteolin 7-O-β-ᴅ-glucopyranoside. The structures were elucidated by means of 1D-, 2D-NMR spectroscopy and mass spectrometry. The topical anti-inflammatory activity of all isolated compounds and extracts was investigated employing the croton oil-induced dermatitis in mouse ear. The most active compound, luteolin, showed an ID50 of 0.3 μmol/cm2 and prevented ear oedema more effectively than an equimolar dose of indomethacin within 24 h.
5 citations
TL;DR: A small series of imidazolylmethylbenzophenone-based compounds, previously reported as CYP19 inhibitors, was tested on new targets, in order to explore the role of a more flexible scaffold for the inhibition of CYP11B1 and -B2 isoforms and confirm the potential of this compound as a wound-healing promoter.
5 citations
TL;DR: Two dichromenoxanthones [1,6-dihydroxy-6′,6′-dimethylpyrano(2′,3′:2,3)-6″,6″-dimethylaminexanthone (brasilixanthone B)], along with betulinic acid, friedelin, sitosterol and stigmasterol were isolated from the roots and stems of Tovomita brasiliensis as discussed by the authors.
Abstract: Two dichromenoxanthones [1,6-dihydroxy-6′,6′-dimethylpyrano(2′,3′:3,4)-6″,6″-dimethylpyrano(2″,3″:7,8)xanthone (brasilixanthone A) and 1,6-dihydroxy-6′,6′-dimethylpyrano(2′,3′:2,3)-6″,6″-dimethylpyrano(2″,3″:7,8 )xanthone (brasilixanthone B)], along with betulinic acid, friedelin, sitosterol and stigmasterol were isolated from the roots and stems of Tovomita brasiliensis . Their structures were characterized on the basis of 1 H and 13 C NMR spectral data, including 2D NMR experiments.
5 citations