Xanthone

About: Xanthone is a research topic. Over the lifetime, 1639 publications have been published within this topic receiving 25870 citations. The topic is also known as: 9-oxo-xanthene & Diphenyline ketone oxide.

Xanthone compound, and preparation method and application thereof

Abstract: The invention discloses a xanthone compound, and a preparation method and application thereof. The xanthone compound is separated from garcinia frutex and named oliganthoneA; the molecular formula is C30H34O7; and the structure of the xanthone compound is disclosed in the specification. The preparation method of the xanthone compound is implemented by extractum extraction, silica gel column chromatography and high pressure liquid chromatography separation by using the garcinia frutex as the raw material. The method concretely comprises the following steps: pulverizing the garcinia frutex sample, extracting, merging the extracting solutions, filtering, and concentrating under reduced pressure to obtain an extractum; extracting the extractum with an organic solvent, filling silica gel in a column, and carrying out silica gel column chromatography on the extract phase; carrying out gradient elution with a solution of n-hexane and acetone in a volume ratio of 1:0-0:1; and separating and purifying the 1:0 part by reverse-phase column chromatography, gel column chromatography and high pressure liquid chromatography to obtain the xanthone compound. The test proves that the xanthone compound has high apoptosis and cell toxicant induction activities and has the advantages of novel structure and high activity; and the xanthone compound can be used as a precursor compound for antineoplastic drugs.

Xanthone 1,4-Dihydropyridine Derivatives with a Potent Selective Bradycardic Effect.

Abstract: A series of xanthone 1,4-dihydropyridine derivatives were prepared. The compounds were evaluated for inotropic, chronotropic and calcium antagonistic properties. The tested compounds are weak calcium antagonists but exert potent selective bradycardic effects.

Analgesic and Anti-Inflammatory Activities of the 2,8-Dihydroxy-1,6-Dimethoxyxanthone from Haploclathra paniculata (Mart) Benth (Guttiferae)

Abstract: In the present study, the pharmacological effects of 2,8-dihydroxy-1,6-dimethoxyxanthone from the bark of Haploclathra paniculata were investigated in mice using in vivo inflammation and nociception models. Acetic acid-induced writhing, paw licking induced by formalin, hot plate, and carrageenan-induced paw edema tests were used to investigate the anti-inflammatory and antinociceptive activities of the xanthone compound. Xanthone, at both doses, inhibited abdominal writhing and the formalin test. At a dose of 20 mg/kg, the time of reaction to the hot plate increased, and significant effects were observed after 30, 60 and 90 min of treatment. At doses of 10 and 20 mg/kg p.o., the 2,8-dihydroxy-1,6-dimethoxyxanthone significantly reduced paw edema at 3 h after the stimulus. The tests also showed no acute toxicity of the xanthone compound in mice. 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging ability was also studied and confirmed the antioxidant activity of the xanthone. To propose the me...