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Xanthone

About: Xanthone is a research topic. Over the lifetime, 1639 publications have been published within this topic receiving 25870 citations. The topic is also known as: 9-oxo-xanthene & Diphenyline ketone oxide.


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Journal ArticleDOI
07 Oct 2021
TL;DR: In this paper, the influence of four xanthone derivatives based on a naturally occurring Xanthone skeleton on the invasiveness of colorectal cancer cells in vitro was investigated.
Abstract: Natural xanthones are a large group of compounds from which promising anticancer properties could be further developed by chemical modifications. This study aimed to investigate the influence of four novel xanthone derivatives based on a naturally occurring xanthone skeleton on the invasiveness of colon cancer cells in vitro. First, the concentrations required to inhibit growth of three colorectal cancer cell lines to 50% (GI50) of all the studied compounds, as well as the natural xanthones used as a reference (gambogic acid and α-mangostin), have been established (MTS reduction test). Next, the assays determining several aspects of the GI25 xanthones influence on colorectal cancer cells, including cytotoxicity, migration and invasion potential, interaction with extracellular matrix and endothelial cells, as well as expression of selected invasiveness related genes have been performed. Our results demonstrate that these novel xanthone derivatives impair colorectal cancer proliferation, motility, adhesion to extracellular matrix and to endothelial cells, and also induce apoptosis and cell death. Moreover, their activity is comparable to cisplatin and 5-fluorouracil, used as reference compounds. Conducted research indicates our compounds for further research and development as novel drugs in colorectal cancer treatment.

4 citations

Journal ArticleDOI
TL;DR: In this paper, the authors used the xanthone-producing cell cultures to identify the transcript for benzaldehyde dehydrogenase (HcBD), a pivotal player in the non-β-oxidative pathway.

4 citations

Journal ArticleDOI
TL;DR: In this article, the identification of the flavonoid (V) and results on the isolation and study of glycosides were presented. But they did not give additional information on the identification and analysis of the V and only showed that the V was 3,8"-bisapigenin.
Abstract: From the epigeal part of Hypericum aucheri Jaub. et Spach we have previously isolated kaempferol, quercetin, myricetin, isoquercitrin, and flavonoid (V) [i] and also 1,3,6,7tetrahydroxyxanthone and its 2-C-glucosid (mangiferin) [2, 3]. On the basis of its UV, IR, PMR, and mass spectra, substance (V) was provisionally identified as 3,8"-bisapigenin [4]. In the present communication we give additional information on the identification of the flavonoid (V) and present results on the isolation and study of glycosides.

4 citations

Journal ArticleDOI
TL;DR: The ethyl acetate extract of the roots of Moutabea guianensis gave 1,6-dihydroxy-4,7,8-trimethoxy-9H-xanthen-9-one, a new xanthone that was isolated by column chromatography on silica gel and the structural elucidation of this compound was established by spectroscopic analyses including 1D and 2D NMR and HRESIMS.
Abstract: The ethyl acetate extract of the roots of Moutabea guianensis gave 1,6-dihydroxy-4,7,8-trimethoxy-9H-xanthen-9-one (1), a new xanthone. The isolation was accomplished by column chromatography on silica gel and the structural elucidation of this compound was established by spectroscopic analyses including 1D and 2D NMR and HRESIMS.

4 citations

Journal ArticleDOI
TL;DR: In this paper, the authors enhance aqueous solubility of xanthone with natural polymers using oil-in-water emulsion and complex coacervation as the microencapsulation techniques.
Abstract: The aim of this study was to enhance aqueous solubility of xanthone with natural polymers using oil-in-water emulsion and complex coacervation as the microencapsulation techniques. There was no int...

4 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202347
202296
202146
202054
201949
201872