Topic
Xanthone
About: Xanthone is a research topic. Over the lifetime, 1639 publications have been published within this topic receiving 25870 citations. The topic is also known as: 9-oxo-xanthene & Diphenyline ketone oxide.
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17 Mar 2017
TL;DR: In this article, 2,3,4-trihydroxy-5-methyl xanthone which has been synthesized from gallic acid and o-cresol in Eaton's reagent was tested for its activity as antimalarial.
Abstract: Xanthone is a phenolic secondary metabolite of Garcinia and Calophyllum herbs which has been clinically proven to display anti malaria activity. In the present paper, 2,3,4-trihydroxy-5-methyl xanthone which has been synthesized from gallic acid and o-cresol in Eaton’s reagent was tested for its activity as antimalarial. Thus, HPIA assay of the synthesized xanthones was successfully conducted. The HPIA assay was carried out towards the xanthone, chloroquine diphosphate as positive control and distilled water as negative control in various concentration. The samples were reacted with hematin (ferriprotoporphyrin IX hydroxide) and the absorbance of the precipitate was observed by using Elisa reader. The results of HPIA assay showed that 2,3,4-trihydroxy-5-methyl xanthone and chloroquine have IC50 values of 0.755 and 1.462 mg/mL or 2.92 and 4.57 mM, respectively. 2,3,4-Trihydroxy-5-methyl xanthone displayed better antimalarial activity than chloroquine.
4 citations
TL;DR: In this paper, the Pictet-Spengler reaction was used to synthesize C-Norcularine from the amino aldehyde (a.k.a., C-Aldehyde).
Abstract: C-Norcularine (2) was synthesized stepwise via the xanthone (3) or by intramolecular Pictet-Spengler reaction directly from the amino aldehyde (10)
4 citations
TL;DR: In this paper , a review provides an overview of the synthesis and ethnomedicinal uses of major xanthones, including α, β, andγ-mangostin, gartanin, and tovophyllin B, isolated and identified from the pericarp of the species G. mangostana.
Abstract: : The extracts of Garcinia mangostana (L) pericarp contain high concentration of prenylated xanthones such as α-, β- and γ-mangostin and related molecules. These extracts possess wide range of biological properties including anticancer, anti-inflammatory, anti-proliferative, antioxidant and pro-apoptotic activities. Till date, α-, β- and γ-mangostin have been extensively studied due to its applications in nutritional supplements, herbal cosmetics and pharmaceutical preparations, but only a few attempts were being made to explore the synthetic utility of these abundantly distributed xanthones. : The data were obtained from several database such as Scopus, Pubmed and Sciencefinder. : This review provides an overview of the synthesis and ethnomedicinal uses of major xanthones, including α, β, andγ-mangostin, gartanin, and tovophyllin B, isolated and identified from the pericarp of the species G. mangostana. The biological and synthetic applications of the compounds obtained after the chemical modification of core xanthone skeleton of major mangostin compounds are also presented in this review. Currently available α-mangostin containing food products, their clinical, pharmacokinetic and safety studies are described. : The main focus of the review is the use of naturally occurring α-, β- and γ-mangostin and their derivatives, as promising scaffolds for new drug discovery.
4 citations
TL;DR: The results on the pharmacological studies of xanthone glycoside and lanceoside suggested that they have a CNS depressant effect.
Abstract: 1-Hydroxy-3,4,7,8-tetramethoxyxanthone, β-sitosterol, uvaol-3-palmitate, and sweroside have been isolated from the fresh whole plant of Tripterospermum lanceolatum (Hayata) Haraex Satake (Gentianaceae). Our results on the pharmacological studies of xanthone glycoside and lanceoside suggested that they have a CNS depressant effect.
4 citations
TL;DR: A new xanthone was isolated from the trunk wood of Haploclathra leiantha and H. paniculata and its structure determined by UV, IR, NMR and mass spectrometry as 1,3,7-trihydroxy-8methoxyxanthone.
4 citations