Topic
Xanthone
About: Xanthone is a research topic. Over the lifetime, 1639 publications have been published within this topic receiving 25870 citations. The topic is also known as: 9-oxo-xanthene & Diphenyline ketone oxide.
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TL;DR: 2-Hydroxyacetyl-7-acetylxanthone (V), a new xanthone derivative, was synthesized in four steps starting from xanthene, by two synthetic approaches and displayed antianaphylactic activity in the PCA test and in the anaphylaxis shock test in rats.
Abstract: 2-Hydroxyacetyl-7-acetylxanthone (V), a new xanthone derivative, was synthesized in four steps starting from xanthene, by two synthetic approaches. The new compound displayed antianaphylactic activity in the PCA test and in the anaphylaxis shock test in rats. It also displayed analgesic activity in the writhing test in mice, and antiinflammatory activity in the carrageenin edema test in rats. The activity of the new compound has been tentatively interpreted on the basis of its chemical and structural analogy with known drugs.
4 citations
TL;DR: In this article, a linear relation between the total luminescence and the concentration of one reactant is derived, showing that the equilibrium constant of certain excited state reactions can be determined from the total fluorescence spectra without the separation of the components and irrespective of the ground state equilibrium.
Abstract: From steady state kinetics of a general excited state reversible reaction scheme, a linear relation between the total luminescence and the concentration of one reactant is derived, showing that the equilibrium constant of certain excited state reactions can be determined from the total fluorescence spectra without the separation of the components and irrespective of the ground state equilibrium. The relation is checked by comparison with published results, and it is applied to the determination of excited state acidity constants of acridone, xanthone and thioxanthone in ethanol-water (1:1).
4 citations
TL;DR: The leaves of Hedysarum denticulatum (140 g) were extracted three times with a c e t o n e w a t e r (1 : 1), the combined extracts were evaporated to half bulk, and the xanthone glycosides were repeatedly extracted with butanol.
Abstract: The leaves of Hedysarum denticulatum (140 g) were extracted three times with a c e t o n e w a t e r (1 : 1), the combined extracts were evaporated to half bulk, and the xanthone glycosides were repeatedly extracted with butanol. The butanolic extracts were evaporated to dryness , and the residue was dissolved in d i o x a n e w a t e r (1 : 1). On standing, the solution deposited substance (I). The mother l iquor of the separat ion of substance (1) was t r ans f e r r ed to a column containing cellulose. Elution was per formed with 5c~ acetic acid. The f irs t f r ac tions contained substance (I), and f rom the subsequent fract ions substance (ID was isolated.
4 citations
TL;DR: Xanthones (9H xanthen-9-one) are an important class of heterocyclic compounds containing oxygen and moiety of gamma-pirone, dense with a two-benzene ring structured, distributed widely in nature as discussed by the authors .
Abstract: Xanthones (9H xanthen-9-one) are an important class of heterocyclic compounds containing oxygen and moiety of gamma-pirone, dense with a two-benzene ring structured, distributed widely in nature. Naturally occurring xanthones are found in micro-organisms and higher plants as secondary metabolites in fungi and lichens. Compounds of the family Calophyllaceae, Guttiferae and Gentianaceae are the most common natural source of xanthones. The structure of xanthones nucleus, coupled with its biogenetic source, imposes that the carbons are numbered according to the biosynthetic pact. The characteristics oxygenation pattern of xanthones earlier is mixed shikimate-acetate biogenesis. The major class of xanthones includes simple oxygenated, non-oxygenated, xanthonolignoids, bisxanthones, prenylated and related xanthones, as well as miscellaneous xanthones. Their great pharmacological importance and interesting scaffolds were highly encouraged by scientists to investigate either the synthesis design or natural products for cancer treatment. Because currently used antitumor drugs possess high toxicity and low selectivity, efficacious treatment may be compromised. This review is limited to the antitumor activity of xanthones and the chemistry of xanthone core, which may help provide fundamental knowledge to the medicinal chemist for new and advanced research in drug development.
4 citations
Journal Article•
TL;DR: In this paper, a method for the separation of xanthone aglycones with monohydroxyphenyl and o-dihydroxymhenyl moieties using aqueous solution of sodium tetraborate was developed.
Abstract: A rapid and effective method for the separation of flavonoid and xanthone aglycones with monohydroxyphenyl and o-dihydroxyphenyl moiety using aqueous solution of sodium tetraborate was developed.
4 citations