Topic
Xanthone
About: Xanthone is a research topic. Over the lifetime, 1639 publications have been published within this topic receiving 25870 citations. The topic is also known as: 9-oxo-xanthene & Diphenyline ketone oxide.
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TL;DR: Two new anthrones were isolated from Harungana madagascariensis in addition to a known anthrone, two xanthones, four anthraquinones and two flavonoids, and were isolated for the first time as genuine natural products.
50 citations
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TL;DR: Five benzophenones and a xanthone, isolated from Hypericum annulatum Moris, were investigated for their protective effect against carbon tetrachloride toxicity in isolated rat hepatocytes and in combination showed statistically significant protection against the toxic agent.
Abstract: Five benzophenones and a xanthone, isolated from Hypericum annulatum Moris, were investigated for their protective effect against carbon tetrachloride toxicity in isolated rat hepatocytes. The benzophenones and the xanthone gentisein were administered alone (100 microM) and in combination with CCl4 (86 microM). CCl4 undergoes dehalogenation in the liver endoplasmic reticulum. This process leads to trichlormethyl radical (*CCl3) formation, initiation of lipid peroxidation, and measurable toxic effects on the hepatocytes. The levels of thiobarbituric acid reactive substances (TBARS) were assayed as an index of lipid peroxidation (LPO). Lactate dehydrogenase (LDH) leakage, cell viability and reduced glutathione (GSH) depletion were used as signs of cytotoxicity. CCl4 significantly decreased hepatocyte viability, GSH level and increased TBARS level and LDH leakage as compared to the control. Our data indicate that 2,3',5',6-tetrahydroxy-4-methoxybenzophenone, 2-O-alpha-L-arabinofuranosyl-3',5',6-trihydroxy-4-methoxybenzophenone and 2-O-alpha-L-3'-acetylarabinofuranosyl-3',5',6-trihydroxy-4-methoxybenzophenone showed weaker toxic effects compared to CCl4 and in combination showed statistically significant protection against the toxic agent.
50 citations
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TL;DR: In this article, two Cerospora betocola toxins, isolated from cultures of the sugar beet pathogen, were identified as tautomeric compounds and named cebetin A (1) and b (2) and their absolute configuration were determined by single-crystal X-ray diffraction.
Abstract: Two Cerospora betocola toxins, isolated from cultures of the sugar beet pathogen, were identified as tautomeric compounds and named cebetin A (1) and cebetin B (2). The structure of cebetin B (2) and its absolute configuration were determined by single-crystal X-ray diffraction. The structure of cebetin A (1) was elucidated on the basis of UV-visible, NMR, and mass spectral data. The molecular backbone of cebetins is totally different from that of the known phytotoxin cercosporin and comprises partially hydrogenated xanthone and anthraquinone moieties connected through two seven-membered rings
50 citations
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TL;DR: Two prenylated xanthone derivatives and one bis-xanthone, designated globulixanthone E, have been isolated from the root bark of Symphonia globulifera and have been shown to exhibit in vitro significant antimicrobial activity against a range of micro-organisms.
50 citations
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TL;DR: Two new compounds, the triterpenoid polypoda (13 E,17 E )-polypoda-7,13,17,21-tetraen-3β-ol and the xanthone E -7-geranyloxy-1,3,7-trihydroxyxanthone have been isolated from the bark of Vietnamese Cratoxylum cochinchinense.
50 citations