Topic
Xanthone
About: Xanthone is a research topic. Over the lifetime, 1639 publications have been published within this topic receiving 25870 citations. The topic is also known as: 9-oxo-xanthene & Diphenyline ketone oxide.
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13 May 2009
TL;DR: Wang et al. as mentioned in this paper revealed a xanthone compound which is taken as a raw material and is subjected to preparative separation by chromatography through a supercritical CO2 extraction technology to obtain demethylbellidifolin anti-hepatitis B virus and liver protection experiments show that the compound has obvious effect on inhibiting hepatitis B viruses, has obvious protection effect on acute or chronic hepatic injury caused by CCl4 and D-aminogalactose, and can be well applied to the preparation of anti-hemorrhages drugs.
Abstract: The invention discloses a xanthone compound The traditional Chinese herbal medicine Swertia davidi Franch is taken as a raw material and is subjected to preparative separation by chromatography through a supercritical CO2 extraction technology to obtain demethylbellidifolin Anti-hepatitis B virus and liver protection experiments show that the compound has obvious effect on inhibiting hepatitis B viruses, has obvious protection effect on acute or chronic hepatic injury caused by CCl4 and D-aminogalactose, and can be well applied to the preparation of anti-hepatitis B virus drugs Compared with the prior solvent extraction method, the supercritical CO2 extraction technology of the preparation method has the characteristics of better process stability and reproducibility, and has the advantages of high total extraction rate of xanthone, high efficiency, short production period, and lower production cost
3 citations
15 Jun 2017
TL;DR: Xanthone amphiphilic compounds are capable of disrupting bacterial membrane through a mechanism called interfacial activity models, and some studies have shown that xanthone derivatives are effective against Staphylococcus aureus, including MRSA.
Abstract: Antibiotic resistance is increasing worldwide and becoming a serious problem for the treatment of patients and also affecting their economy. One instance of bacteria that is resistant to the antibiotic is Methicillin- Resistant Staphylococcus aureus (MRSA). MRSA infections are fatal and even deadly. Some MRSA strain has shown resistance towards currently available antibacterial agents. To overcome this, we need new compound alternatives. One of the compounds currently being developed is xanthone derivatives. Xanthones can be found in many kinds of plants, including Garcinia mangostana , in which the active compounds are mangostanin and ±-mangostin. Xanthones is effective against several types of Grampositive and Gram-negative bacterias, including Staphylococcus species. Some studies have shown that xanthone derivatives are effective against Staphylococcus aureus, including MRSA. One of the proposed mechanisms of xanthone's antibacterial activity is the involvement of the bacteria's cytoplasmic membrane. Xanthone amphiphilic compounds are capable of disrupting bacterial membrane through a mechanism called interfacial activity models. Xanthone can also act as the antioxidant and by inducing the release of lipoteichoic acid (LTA) from the cell wall of MRSA. LTA is the main constituent of the cell wall of Gram-positive bacteria, which are covalently bonded to the outside of peptidoglycan. This structure is important for cell division and bacterial osmotic protection. Thus, it is believed that the mechanism of action of xanthones involved damaging bacterial cell membrane.
3 citations
28 May 2020
TL;DR: Investigation for the base found NaH as an optimal base to avoid the dimerization of 3-(1-alkynyl) chromones and the potential of other N-heterocycle glycine ester anions to give the novel functional 2-nitrogen-derived xanthones.
Abstract: A silver-catalyzed dimerization of ethyl isocyanoacetates could trigger the tandem reaction of 3-(1-alkynyl) chromones under the basic condition in a one-pot reaction to afford xanthone skeletons w...
3 citations
TL;DR: In this article , nine xanthone derivatives (1−9) were isolated from the roots of Polygala azizsancarii, which is a narrow endemic species for the flora of Türkiye.
Abstract: Nine xanthone derivatives (1–9) were isolated from the roots of Polygala azizsancarii, which is a narrow endemic species for the flora of Türkiye. Based on all of the evidence, the structures of 1–9 were established as two previously undescribed xanthone O‐glucosides, 3‐O‐β‐D‐glucopyranosyloxy‐1,6‐dihydroxy‐2,5,7‐trimethoxyxanthone (1), 3‐O‐β‐D‐glucopyranosyloxy‐1,6‐dihydroxy‐2,7‐dimethoxyxanthone (2), and seven previously described xanthones, 1,3,6‐trihydroxy‐2,5,7‐trimethoxyxanthone (3), 1,3,6‐trihydroxy‐2,7‐dimethoxyxanthone (4), 1,2,3,4,7‐pentamethoxyxanthone (5), 1,3‐dihydroxy‐2,5,6,7‐tetramethoxyxanthone (6), 1,3‐dihydroxy‐4,7‐dimethoxyxanthone (7), 1,7‐dihydroxy‐3‐methoxyxanthone (8), and 1,7‐dihydroxy‐2,3‐methylenedioxyxanthone (9). The structures of the compounds were determined by spectroscopic methods, including 1D‐NMR (1H‐NMR, 13C‐NMR, DEPT‐135), 2D‐NMR (COSY, NOESY, HSQC, HMBC, INADEQUATE), and HR‐MS. The solid‐state structures of 1–4, including the absolute configurations of the stereogenic carbons of the sugar moiety in 1 and 2, were established by X‐ray crystal‐structure analyses. For the newly described compounds, the trivial names sancarosides A (1) and B (2) are proposed.
3 citations
TL;DR: Xanthone and 1-hydroxyxanthone polymers were prepared by the Kostanecki reaction on salicylic acid-formaldehyde and 4-(amino, chloro, and bromo)-salicylic ac-fentaldehyde polymers, respectively, with phenol and resorcinol as discussed by the authors.
Abstract: Xanthone and 1-hydroxyxanthone polymers were prepared by the Kostanecki reaction on salicylic acid-formaldehyde and 4-(amino, chloro, and bromo)-salicylic acid-formaldehyde polymers, respectively, with phenol and resorcinol. All the xanthone polymer samples were characterized by elemental analysis, by IR spectral study, and by TGA. Xanthone polymers were also screened for their antifungal activity against a variety of fungi.
3 citations