Topic
Xanthone
About: Xanthone is a research topic. Over the lifetime, 1639 publications have been published within this topic receiving 25870 citations. The topic is also known as: 9-oxo-xanthene & Diphenyline ketone oxide.
Papers published on a yearly basis
Papers
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TL;DR: The introduction of a 2,3-lactone ring improved the negative inotropic activity and selectivity of xanthone 1,4-dihydropyridine derivatives.
Abstract: A series of xanthone 1,4-dihydropyridine derivatives bearing a 2,3-lactone ring and a 2-acetoxymethyl group were prepared. The compounds were evaluated for inotropic, chronotropic and calcium antagonist properties. The introduction of a 2,3-lactone ring improved the negative inotropic activity and selectivity.
2 citations
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15 Sep 2017
TL;DR: In this paper, the xanthone compound CCE9 is used for preparing a drug for treating cancer by activating p38MAPK, Bcl-2 is phosphorylated, Bax is activated, so that sub tumor cell apoptosis is induced.
Abstract: The invention discloses application of a xanthone compound CCE9. The xanthone compound CCE9 is used for preparing a drug for treating cancer. By activating p38MAPK, Bcl-2 is phosphorylated, the conformation of Bcl-2 is changed, and Bax is activated, so that sub tumor cell apoptosis is induced. Therefore, the xanthone compound CCE9 can be used for preparing a drug taking Bcl-2 as an action target spot for treating cancer. In addition, Bcl-2 which is phosphorylated can be used as the action target spot for screening the xanthone compound.
2 citations
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TL;DR: All compounds showed an antiproliferative activity with an IC50 value down to ∼11 µM for isogarcinol, and were evaluated against the human breast cancer cell line MCF-7.
2 citations
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TL;DR: A series of xanthone derivatives (2a-2e) as telomeric quadruplex stabilizing ligands were designed, synthesized and evaluated by molecular docking, drug-likeness prediction, spectroscopy assay, melting profiles, PCR stop analysis as mentioned in this paper .
2 citations
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TL;DR: Two nitro substituted acridones were endowed with a remarkable profile against the majority of the cell lines tested, with IC50 values in the low micromolar range, suggesting their further evaluation in various pathophysiological environments, conditions, and regimens.
2 citations