Topic
Xanthone
About: Xanthone is a research topic. Over the lifetime, 1639 publications have been published within this topic receiving 25870 citations. The topic is also known as: 9-oxo-xanthene & Diphenyline ketone oxide.
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Patent•
10 Jul 2006
TL;DR: In this paper, a method for producing a xanthone compound having a semaphorin inhibitory activity and to obtain its intermediate is provided, which comprises a process for subjecting a compound represented by formula (1) [R 1 is a hydrogen atom or a group represented by the formula (2) (R 4 is a substituted or nonsubstituted 1-6C alkyl group or the like); R 2 and R 3 are each the same or different and a substituted/non-substitized 1- 6C alkoxy group or a like]
Abstract: PROBLEM TO BE SOLVED: To provide a method for producing a xanthone compound having a semaphorin inhibitory activity and to obtain its intermediate. SOLUTION: The method for producing a xanthone compound comprises a process for subjecting a compound represented by formula (1) [R 1 is a hydrogen atom or a group represented by formula (2) (R 4 is a substituted or nonsubstituted 1-6C alkyl group or the like); R 2 and R 3 are each the same or different and a substituted or nonsubstituted 1-6C alkoxy group or the like] to two molecule condensation to give a compound represented by formula (4). COPYRIGHT: (C)2008,JPO&INPIT
2 citations
TL;DR: In this article, a reported synthesis of 5,8-dihydroxy-1,3-dimethoxyxanthone from the reaction of 3,5dimethoxyphenol with 2-(methoxycarbonyl)-1,4-benzoquinone resulted in the identification of the product as the isomer of benzo[c]coumarin, established by X-ray crystallography.
Abstract: Reinvestigation of a reported synthesis of 5,8-dihydroxy-1,3-dimethoxyxanthone from the reaction of 3,5-dimethoxyphenol with 2-(methoxycarbonyl)-1,4-benzoquinone resulted in the identification of the product as the isomer of benzo[c]coumarin, i.e., 7,10-dihydroxy-1,3-dimethoxy-6H-dibenzo[b,d]pyran-6-one, established by X-ray crystallography. This requires the revision of the structures of the derivatives that were reported.
2 citations
TL;DR: Three new xanthone dimers are explored from the dichloromethane extract of Usnea baileyi and their structures were elucidated unambiguously by spectroscopic analyses, including high resolution electrospray ionisation mass spectrometry (HRESIMS), nuclear magnetic resonance spectroscopy (NMR), and DP4 probability.
2 citations
Journal Article•
TL;DR: In this article, the chemical constituents of Erigeron breviscapus (Vant.) Hand were investigated and two compounds were identified as 1 hydroxy 2,3,5 trimethoxy xanthone (Ⅴ), and 1 (2′ γ pyranone) 6 caffeoyl α D pyranologlucose (υ�) showed inhibitory effects on the adhesion of endothelial induced by TNF α, indicating its protection against injury due to ischemic reperfusion.
Abstract: Object To investigate the chemical constituents of Erigeron breviscapus (Vant.) Hand. Mazz. (Compositae) Methods Compounds were isolated from the ethanolic extract with column chromatography and identified on the basis of spectral analysis (IR, EI MS, FAB MS, 1HNMR, 13 CNMR, 2DNMR) and physiochemical properties Results Two compounds were identified as 1 hydroxy 2,3,5 trimethoxy xanthone (Ⅴ), and 1 (2′ γ pyranone) 6 caffeoyl α D pyranoglucose (Ⅵ) Conclusion Both of the two compounds were new Compound Ⅵ showed inhibitory effects on the adhesion of endothelial induced by TNF α, indicating its protective effect against injury due to ischemic reperfusion
2 citations
TL;DR: Alkanolamines derivatives of xanthone, synthesized by of the reaction of an appropriate aminoalcohol with corresponding 2-bromomethylxanthones, displayed anti MES activity with a protective index in the range 2.21-5.84 corresponding with that for phenytoin, carbamazepine and valproate.
Abstract: Synthesis and physicochemical properties of alkanolamine derivatives of xanthone are described. Alkanolamines were synthesized by of the reaction of an appropriate aminoalcohol with corresponding 2-bromomethylxanthones. The obtained compounds 1-13 were evaluated for anticonvulsant activity in the maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole seizure threshold (scMet) assays and for neurotoxicity (TOX). Several alkanolamines were found to be active in both the anticonvulsant tests. Most interesting were the 2-amino-1-propanol-, 1-amino-2-propanol- or 1-amino-2-butanol derivatives of 6-methoxy- or 6-chloroxanthone, which displayed anti MES activity with a protective index (TD50/ED50) in the range 2.21-5.84 corresponding with that for phenytoin, carbamazepine and valproate.
2 citations