Topic
Xanthone
About: Xanthone is a research topic. Over the lifetime, 1639 publications have been published within this topic receiving 25870 citations. The topic is also known as: 9-oxo-xanthene & Diphenyline ketone oxide.
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TL;DR: A new prenylated acridone alkaloid medicacridone (I) and a new ferulate xanthone, medicaxanthone (II) are isolated along with 11 known compounds from the methanol extract of the bark of Citrus medica as discussed by the authors.
Abstract: A new prenylated acridone alkaloid medicacridone (I) and a new ferulate xanthone, medicaxanthone (II) are isolated along with 11 known compounds from the methanol extract of the bark of Citrus medica. Some of the compounds show weak cytotoxic activity against the human Caucasian prostate adenocarcinoma cell line PC-3.
1 citations
TL;DR: In this article, a new xanthone metabolite (Hypoxylon Xanthone A) was identified based on HR-ESI-MS, 1D-, 2D-NMR spectra and the comparison of the experimental and calculated ECD spectra.
Abstract:
Hypoxylon sp. was used to ferment at 25°C for 45 days. The solid culture of Hypoxylon sp.
was extracted with 75% EtOH under ultrasonic for twice. And the dried combined extracts were then
suspended in H2O and partitioned with ethyl acetate. EtOAc extracts were subjected to a silica gel column
and eluted with petroleum ether - acetone to a.ord seven fractions. Sephadex LH-20 and RPHPLC
were used subsequently to yield a novel xanthone metabolite (Hypoxylon xanthone A). Its structure
was elucidated based on HR-ESI-MS, 1D-, 2D-NMR spectra, and the comparison of the experimental
and calculated ECD spectra. The anti-neuroinflammatory assay of Hypoxylon xanthone A, as
manifested by the inhibitory effect on LPS-induced NO production in BV-2 microglial cells, indicated
almost the same inhibitory effect as minocycline in a dose-dependent manner within the concentration
of 1-50 μM, suggesting that Hypoxylon xanthone A could be a new potential neuroinflammation inhibitor.
1 citations
Patent•
08 Nov 1973
TL;DR: In this paper, substituted xanthone carboxylic acid compound is used in the treatment of allergic conditions and method for preparing these compounds and compositions and intermediates therein are also disclosed.
Abstract: Compounds containing and method employing, as the essential ingredient, novel substituted xanthone carboxylic acid compound which are useful in the treatment of allergic conditions. Method for preparing these compounds and compositions and intermediates therein are also disclosed. 7-Trifluoromethylxanthone-2-carboxylic acid is illustrated as representative of the class.
1 citations
TL;DR: It is revealed that mangiferin has potent antioxidant effect against arsenic trioxide induced toxicity in rat myocardium and which may be attributed to decrease in arsenic induced reactive oxygen species levels and resultant oxidative stress.
Abstract: Mangiferin, a glucosylxanthone found in Mangifera indica, reported to have a wide range of pharmacological properties. The objective of this study was to evaluate the antioxidant potential of mangiferin against arsenic trioxide induced myocardial oxidative stress in rats. Our earlier studies have revealed the oxidative stress inducing capacity of arsenic trioxide (As2O3), hence in the present study we have administered 4 mg/kg bwt of As2O3 to generate oxidative stress in myocardium. The antioxidant effect of mangiferin against arsenic induced toxicity was assessed by using biochemical parameters like reduced glutathione (GSH), glutathione-S-transferase (GST), glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT) and thiobarbituric acid reactive substances (TBARS). Cotreatment with mangiferin (100 mg/kg b.wt) for 30 days significantly (p < 0.05) inhibited the arsenic induced decrease in GSH, GST, GPx, SOD, and CAT levels. The mangiferin also protected the heart from lipid peroxidation. Taken together, our study revealed that mangiferin has potent antioxidant effect against arsenic trioxide induced toxicity in rat myocardium and which may be attributed to decrease in arsenic induced reactive oxygen species levels and resultant oxidative stress.
1 citations