Topic
Xanthone
About: Xanthone is a research topic. Over the lifetime, 1639 publications have been published within this topic receiving 25870 citations. The topic is also known as: 9-oxo-xanthene & Diphenyline ketone oxide.
Papers published on a yearly basis
Papers
More filters
TL;DR: 12 known compounds of xanthone derivative, named inoxanthone, together with their structures were established on the basis of spectral evidence and their antibacterial activity and potency against a wide range of micro organisms were evaluated.
147 citations
TL;DR: An ethanol extract of the fruit case of Garcinia mangostan showed potent α-glucosidase inhibitory activity and the actual pharmacological potential of the ethanol extract was demonstrated by showing that it could elicit reduction of postprandial blood glucose levels.
139 citations
TL;DR: The goal to find new potent inhibitors of aromatase was reached with the xanthone derivatives 22d,e and 22g-i, which exceeded the potency of the known reference drug fadrozole and also showed high selectivity with respect to P450 17.
Abstract: Aromatase (P450arom) is a target of pharmacological interest for the treatment of breast cancer. In this paper, we report the design, synthesis, and in vitro biological evaluation of a series of new (di)benzopyranone-based inhibitors of this enzyme. The design of the new compounds was guided by a CoMFA model previously developed for a series of nonsteroidal aromatase inhibitors. Both the chromone and the xanthone nuclei were taken as molecular skeletons, and the functions supposed to be critical for binding to the aromatase active site − a heterocyclic ring (imidazole or 1,3,4-triazole) linked to the aromatic moiety by a methylene unit and an H-bond accepting function (CN, NO2, Br) located on the aromatic ring at a suitable distance from the heterocyclic nitrogen carrying the lone pair − were attached to them. The chromone, xanthone, and flavone derivatives were prepared by conventional synthetic methods from the appropriate methyl analogues. Aromatase inhibitory activities were determined by the method o...
126 citations
TL;DR: Flow cytometric histograms revealed a specific pattern; that is, lawsone and juglone in the naphthaquinone group and alizarin and 1,8-dihydroxy-anthraquin one in the anthraquinones group blocked mainly the S phase of the cell cycle.
Abstract: Quinones were studied for their growth inhibitory effect on cultured malignant cells. HCT-15 cells derived from human colon carcinoma were used for these experiments. Quinones used were arbutin in the benzoquinone group, juglone and lawsone in the naphthaquinone group, alizarin, emodin, 1,8-dihydroxyanthraquinone, and anthraquinone in the anthraquinone group, and xanthone. Cultured cells were incubated with various concentrations of the quinones for four days in a 5% C02 incubator, after which cell numbers were counted and significance of differences was analyzed by Student's t test. Anthraquinones and naphthaquinones used in these experiments were more effective than the monocyclic quinone. The 50% suppression dose was less than 12.5 μg/ml for them. The number of OH groups seemed to play an important role in the degree of the cell growth inhibition: anthraquinones with 2 or 3 OH groups were more effective than those with no OH group like, 9,10-dioxoanthracene and xanthone. In fact, anthraquinones with no...
114 citations
TL;DR: Xanthone production in Hypericum perforatum suspension cultures in response to elicitation by Agrobacterium tumefaciens co-cultivation has been studied and revealed that xanthones play dual function in plant cells during biotic stress: as antioxidants to protect the cells from oxidative damage and as phytoalexins to impair the pathogen growth.
112 citations