Topic
Xanthone
About: Xanthone is a research topic. Over the lifetime, 1639 publications have been published within this topic receiving 25870 citations. The topic is also known as: 9-oxo-xanthene & Diphenyline ketone oxide.
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TL;DR: In this paper, a total synthesis of atroviridin (1 ) based on biosynthetic principles is presented. But the synthesis of the natural product was constructed by coupling aryl bromide 8 with aldehyde 7 and subsequent intramolecular conjugate addition on a quinone precursor.
28 citations
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TL;DR: A new polyprenylated xanthone (9H-xanthen-9-one) and a new poly prenyl-ated benzophenone (6) were isolated from the bark of Garcinia oblongifolia, together with five known compounds including the four xanthones 3-5 and 7 and a benzphenone 6.
Abstract: A new polyprenylated xanthone (=9H-xanthen-9-one) and a new polyprenylated benzophenone, namely oblongifolixanthone A (1) and garciniagifolone A (2), were isolated from the bark of Garcinia oblongifolia, together with five known compounds including the four xanthones 3–5 and 7 and a benzophenone 6. The structures of 1 and 2 were established by detailed analysis of their spectroscopic data, especially 1D- and 2D-NMR spectra and HR-ESI-MS data. All these compounds were assayed for their cytotoxic activities against three human tumor cell lines (HeLa, SGC7901, and HepG2). The 1,3,6,7-tetrahydroxy-9H-xanthen-9-one (3) was inactive, and the other compounds showed weak to moderate activity.
28 citations
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TL;DR: A new xanthone derivative was isolated together with other 13 known constituents from a Chinese natural medicine, Swertia pseudochinensis HARA and exhibited significant hepatoprotective activities at a dose showing no hepatoxicity.
Abstract: A new xanthone derivative was isolated together with other 13 known constituents from a Chinese natural medicine, Swertia pseudochinensis HARA. Their structures were determined based on the spectral and chemical evidences. Furthermore, respective hexane, ethyl acetate, 1-BuOH, MeOH and water extracts of S. pseudochinensis, and purified compounds were respectively evaluated for their hepatoprotective activities against hepatocyte injury induced by CCl4. All the extracts and isolated compounds exhibited significant hepatoprotective activities at a dose showing no hepatoxicity.
28 citations
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TL;DR: 1,2-Dimethoxy-5-hydroxyxanthone was isolated from the twigs of Mammea siamensis, in addition to six known xanthones, and structures for these compounds were deduced from their spectral data.
28 citations
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TL;DR: Two new xanthones, 1,5,6-trihydroxy-3-methoxy-4-(3-hydroxyl- 3-methylbutyl)xanthone (1) and 1,3,5-triHydroxy-6',6'-dimethyl-2H-pyrano(2',3':6,7)-2-enyl (2), have been isolated from the stems of Garcinia cowa.
Abstract: Two new xanthones, 1,5,6-trihydroxy-3-methoxy-4-(3-hydroxyl-3-methylbutyl)xanthone (1) and 1,5-dihydroxy-3-methoxy-6′,6′-dimethyl-2H-pyrano(2′,3′:6,7)-4-(3-methylbut-2-enyl)xanthone (2), have been isolated together with six known xanthones: 1,3,5-trihydroxy-6′,6′-dimethyl-2H-pyrano(2′,3′:6,7)xanthone (3), dulxanthone A (4), 1,5,6-trihydroxy-3,7-dimethoxyxanthone (5), 1,7-dihydroxyxanthone (6), 1,3,5-trihydroxy-6-methoxyxanthone (7), 1,3,6,7-tetrahydroxyxanthone (8), from the stems of Garcinia cowa (Guttiferae).
28 citations