Topic
Xanthone
About: Xanthone is a research topic. Over the lifetime, 1639 publications have been published within this topic receiving 25870 citations. The topic is also known as: 9-oxo-xanthene & Diphenyline ketone oxide.
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TL;DR: Two new xanthone derivatives are reported from Psorospermum febrifugum var ferrugineum and a known 2-methoxy-3-hydroxyxanthone and their structures were elucidated by extensive analysis of 1H and 13C nmr, ms, and chemical correlations.
Abstract: The isolation and structural determination of two new xanthone derivatives, 1,2,4-trimethoxy-3,8-dihydroxyxanthone, 1,2,4-trimethoxy-3-hydroxyxanthone and a known 2-methoxy-3-hydroxyxanthone from Psorospermum febrifugum var. ferrugineum are reported. The structures were elucidated by extensive analysis of 1H and 13C nmr, ms, and chemical correlations.
23 citations
TL;DR: Xanthone is a heterocyclic compound with a dibenzo-γ-pyrone framework and well known to have privileged structures for anticancer activities against several cancer cell lines as mentioned in this paper.
Abstract: The annual number of cancer deaths continues increasing every day; thus, it is urgent to search for and find active, selective, and efficient anticancer drugs as soon as possible. Among the available anticancer drugs, almost all of them contain heterocyclic moiety in their chemical structure. Xanthone is a heterocyclic compound with a dibenzo-γ-pyrone framework and well-known to have “privileged structures” for anticancer activities against several cancer cell lines. The wide anticancer activity of xanthones is produced by caspase activation, RNA binding, DNA cross-linking, as well as P-gp, kinase, aromatase, and topoisomerase inhibition. This anticancer activity depends on the type, number, and position of the attached functional groups in the xanthone skeleton. This review discusses the recent advances in the anticancer activity of xanthone derivatives, both from natural products isolation and synthesis methods, as the anticancer agent through in vitro, in vivo, and clinical assays.
23 citations
TL;DR: An investigation of the stem bark of Garcinia ovalifolia oliv. (Guttiferae) has revealed the presence of large quantities of the polyisoprenyl benzophenone xanthochymol as mentioned in this paper.
Abstract: An investigation of the stem bark of Garcinia ovalifolia oliv. (Guttiferae) has revealed the presence of large quantities of the polyisoprenyl benzophenone xanthochymol. Isoxanthochymol was identified as a minor component. In addition the bark yielded small amounts of a tetraoxygenated xanthone which was shown to be identical with the known compound macluraxanthone, otherwise found only in the Moraceae. The common triterpenes friedelin and sitosterol were also present. The biological significance of these findings is briefly discussed.
22 citations
TL;DR: In this article, a new synthetic approach to angularly-fused and simpler substituted xanthones is described based upon the benzannulation of 2-(o-anisoyl)-4-hetero-aryl-2-cyclobutenones and 2-(2-(1,3-dithian)-2-yl)-4alkenyl-2.
22 citations
Journal Article•
TL;DR: A benzophenone, 2,2',5,6'-tetrahydroxybenzophenone (1), and one xanthone, 5-hydroxy-3methoxyxanthone (2), were newly described as natural products from the leaves and the stem barks of Hypericum lanceolatum.
Abstract: A benzophenone, 2,2’,5,6’-tetrahydroxybenzophenone (1), and one xanthone, 5-hydroxy-3methoxyxanthone (2), were newly described as natural products from the leaves and the stem barks of Hypericum lanceolatum, along with the known compounds friedelin (3), betulinic acid (4), allanxanthone A (5), 1,3,6-trihydroxyxanthone (6), isogarcinol (7), sitosterol 3-O-β-D-glucopyranoside (8), 1-hydroxy-6methoxyxanthone (9), 6,7-dihydroxy-1,3-dimethoxyxanthone (10), 3-hydroxy-5-methoxyxanthone (11), 1,7dihydroxy-3,6-dimethoxyxanthone (12) and calophyllumin A (13). Their structures were elucidated by spectroscopic means and comparison with published data.
22 citations