Topic
Xanthone
About: Xanthone is a research topic. Over the lifetime, 1639 publications have been published within this topic receiving 25870 citations. The topic is also known as: 9-oxo-xanthene & Diphenyline ketone oxide.
Papers published on a yearly basis
Papers
More filters
TL;DR: Two new xanthone glycosides have been isolated from the root of Gentiana lutea on the basis of spectroscopic evidence and have been determined as 7-hydroxy-3-methoxy-1- O -primeverosylxanthone and 1-hydroxyphenyl Xanthone.
20 citations
TL;DR: In this paper, a highly convergent approach was developed to achieve the first asymmetric and scalable total synthesis of FD-594, a complex polycyclic xanthone natural product from Streptomyces sp. TA-0256, in a longest linear sequence of 20 steps.
Abstract: A highly convergent approach was developed to achieve the first asymmetric and scalable total synthesis of FD-594, a complex polycyclic xanthone natural product from Streptomyces sp. TA-0256, in a longest linear sequence (LLS) of 20 steps. The trans-9,10-dihydrophenanthrene-9,10-diol fragment (B-C-D ring) was generated through a new strategy involving asymmetric dihydroxylation followed by Cu-mediated oxidative cyclization. Late-stage stereoselective glycosylation assembled the angular hexacyclic framework with a β-linked 2,6-dideoxy trisaccharide fragment.
20 citations
TL;DR: A new xanthone O-glycoside, 3-O-(6-O-α-L-arabinopyranosyl)-β-D-glucopyranoyl-1,4dimethoxyxanthone (1), together with three known compounds, phomapyrone D (2), 2methoxy-3,4-methylenedioxybenzophenone (3), and cyclo(D-6-Hyp-L -Phe) (4), was isolated from the mangrove endophytic fungus
Abstract: A new xanthone O-glycoside, 3-O-(6-O-α-L-arabinopyranosyl)-β-D-glucopyranosyl-1,4-dimethoxyxanthone (1), together with three known compounds, phomapyrone D (2), 2-methoxy-3,4-methylenedioxybenzophenone (3), and cyclo(D-6-Hyp-L-Phe) (4), was isolated from the mangrove endophytic fungus, Phomopsis sp. (ZH76). Their structures were determined by analysis of spectroscopic data. Compound 1 inhibited HEp-2 and HepG2 cells with IC50 values of 9 and 16 μmol/mL, respectively.
20 citations
TL;DR: In this article, the condensation reaction of ketones with iminodimagnesium reagents (RN(MgBr)2) derived from various primary amines as well as 1,1-disubstituted hydrazines was investigated.
Abstract: The condensation reaction of ketones with iminodimagnesium reagents (RN(MgBr)2) derived from various primary amines as well as 1,1-disubstituted hydrazines was investigated. N-Arylimines and 1-methyl-1-phenylhydrazones of diaryl ketones were prepared, their yields being affected by the electronic and positional effects of substituents of reagent and substrate. Direct preparation of some anils of xanthone and its 1-methyl-1-phenylhydrazone was achieved by use of the corresponding iminodimagnesium reagents.
20 citations
TL;DR: In this paper, a chiral xanthone with a 1,5,7-trimethyl-3-azabicyclo-[3.3.1]nonan-2-one backbone was employed in catalytic quantities (5 mol%) to achieve a deracemization reaction of racemic benzothiazinone-1-oxides in acetonitrile solution.
Abstract: Several chiral sulfoxides with a lactam hydrogen-bonding site were prepared and their photochemical behavior was studied in the presence of xanthone and thioxanthone sensitizers. While acyclic sulfoxides showed only decomposition, chiral benzothiazinone-1-oxides with a stereogenic sulfur atom underwent a stereomutation upon irradiation at λ = 366 nm in the presence of catalytic quantities of a xanthone sensitizer. A chiral xanthone with a 1,5,7-trimethyl-3-azabicyclo-[3.3.1]nonan-2-one backbone was employed in catalytic quantities (5 mol%) to achieve a deracemization reaction of racemic benzothiazinone-1-oxides in acetonitrile solution. Five substrates could be successfully deracemized in good yields and with up to 55% ee.
20 citations