Xylopia aethiopica

About: Xylopia aethiopica is a research topic. Over the lifetime, 347 publications have been published within this topic receiving 5511 citations.

Antidiabetic Screening of Phenolic-rich Extracts of Selected Medicinal Spices

Abstract: Medicinal spices are used by herbal practitioners as condiments in decoctions for management of diabetes and its associated complications. The study assessed and compared the potentials of phenolic-rich extracts from four selected medicinal spices: Curcuma longa; Allium sativum; Xylopia aethiopica and Syzygium aromaticum to delay carbohydrate digestion, scavenge free radicals and ameliorate hyperglycemia. Results showed that the seed of X. aethiopica has the highest phenolic content (19.25 ± 0.96 mg/g) while C. longa extracts was the lowest (10.42 ± 0.86 mg/g). Dose-dependent in vitro bioactivities were exhibited by all the spice extracts, with the best antiradical (EC50 = 64.98 ± 5.16 µg/ml) and α-amylase inhibitory (IC50 = 11.33 ± 1.10 µg/ml) activities displayed by A. sativum and S. aromaticum, respectively. Intraperitoneal administration of either of the spice extracts for 5 days caused significant reduction (> 80%) in hyperglycemia. The antidiabetic activities of the spice extracts may be attributed to the presence of notable secondary metabolites such as tumerone and its derivatives in C. longa extract or eugenol that was the main constituent of the extract from S. aromaticum and also found in minor quantities in A. sativum and X. aethiopica extracts. These findings showed that extract from these spices could be explored as a functional component of foods or as candidates for development of oral antihyperglycemic agents for the management of diabetes mellitus.

GC-MS/FT-IR screening of Xylopia aethiopica (Dunal) A. Rich Fruit

Abstract: The present study was aimed at identifying the functional groups and phyto-constituents present in Xylopia aethiopica (Dunal) A Rich fruit using Fourier Transform Infrared Spectrometry (FTIR) and Gas chromatography-mass spectroscopy (GC-MS), spectroscopy. FTIR method was performed using Perkin Elmer Spectrophotometer and the characteristic peaks were detected. The phytochemical constituents were screened by GC-MS method and the compound detection employed the NIST Ver. 2.0 year 2005 library. The results of the GC-MS analysis showed different peaks determining the presence of 15 phytochemical compounds in the fruit extract of A. aetiopica. The phyto-constituents with their percentage areas include β-Ylangene(2.85%), 1,6-Cyclodecadiene, 1-methyl-5-methylene-8- (1-methylene)-, [s-(E,E)]- (1.71%); (-)-Spathulenol (1.23%);Trans-Z-α-Bisabolene epoxide (1.68%); n-Hexadecanoic acid (2.90%); Manoyl oxide (2.51%); Linoleic acid (8.14%); Oleic acid (3.13%); Cis-Z-α-Bisabolene (1.34%); Pimara-7,15-diene-3-one (8.86%); 1-Heptatricotanol (2.07%); Kaur-1b-ene (6.59%); β-Pimaric acid (36.39%); Doconexent (1.66%) and Androstan-17-one, 3-ethyl-3-hydroxyl-, (5a)- (17.48%). The result of the FTIR spectroscopic studies revealed the presence of arenes, alcohols, phenols, carboxylic acids, ethers, aromatics, aryl ketone, alkenes, saturated aldehyde and phenols. The findings of the study revealed that the GC-MS and FTIR spectral analyses of Xylopia aethiopica (Dunal) A. Rich fruit extract composed of various bioactive compounds which have are used in ethnomedicine to treat and cure infections and diseases. Key words: Fourier Transform Infrared Spectrometry (FTIR), Gas chromatography-mass spectroscopy (GC-MS), phytochemical, Xylopia aethiopica.