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Xylopia aethiopica

About: Xylopia aethiopica is a research topic. Over the lifetime, 347 publications have been published within this topic receiving 5511 citations.


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Journal ArticleDOI
TL;DR: The study revealed the spatial variability, differential behaviours and specificity of the selected kaurane diterpenes in the fruit, seed and pericarp of X. aethiopica.
Abstract: Introduction Kaurane diterpenes, notably xylopic acid, have demonstrated important biological activities including analgesia, anti-oxidant, antimicrobial and cytotoxicity. The fruits of Xylopia aethiopica have been reported to be a rich source of kaurane diterpenes. Objective An analytical approach for detailed imaging and characterisation of selected kaurane diterpenes was developed using matrix-assisted laser desorption/ionisation high-resolution mass spectrometry (MALDI-HRMS) imaging techniques and high-performance liquid chromatography-high resolution electrospray ionisation-tandem mass spectrometry (HPLC-HRESI-MSn ) studies, respectively. Methods The images of the compounds were constructed based on selected ions from their HRESI-MS spectra. The matrix employed comprised a solution of α-cyano-4-hydroxycinnamic acid (HCCA) in acetonitrile-water with trifluoroacetic acid (TFA). HPLC-HRESI-MSn measurements were conducted on an LTQ-Orbitrap spectrometer equipped with a heated electrospray ionisation (HESI)-II source. Results The analytical strategy adopted showed the spatial distribution of the compounds in the fruits of X. aethiopica based on the dominant ions at m/z 301.2163 [M + H - HOCOCH3 ]+ and m/z 399.1932 [M + K]+ for xylopic acid, m/z 317.2111 [M + H]+ and m/z 355.1670 [M + K]+ for 15-oxo-ent-kaur-16-en-19-oic acid and m/z 303.2319 [M + H]+ for ent-kaur-16-en-19-oic acid. The fragmentation patterns of the compounds were proposed based on the HRESI-MSn measurements. Conclusions The study revealed the spatial variability, differential behaviours and specificity of the selected kaurane diterpenes in the fruit, seed and pericarp. The compounds under study were predominantly restricted to the pericarp of the fruit with trace amounts in the seed.

4 citations

M Kabir, MZ Iqbal, M Shafiq, Z Farooqi, UE Habiba 
18 Feb 2020
TL;DR: The study proves the effectiveness of the plant extracts in the control of human pathogens by demonstrating the inhibitory effect of plant extracts against S. aureus, E. coli and Pseudomonas spp.
Abstract: A study was carried out to evaluate the effects of phytochemical properties of plant extracts of Xylopia aethiopica, Citrus limon and Allium sativum on selected human pathogens. Phytochemical analysis of ethanol and chloroform of Xylopia aethiopica, Citrus limon and Allium sativum extracts showed presence of flavonoid, alkaloid, HCN, saponin, tannin and sterol. Quantitative phytochemical analysis of C. limon, X. aethiopica and A. sativum revealed C. limon has highest flavonoid (2.635 ± 0.021), sterol (0.160 ± 0.000), terpenoid (0.520 ± 0.000) and anthraquinone (2.760 ± 0.057). X. aethiopica has highest composition of hydrogen cyanide (0.835 ± 0.021) while A. sativum has highest composition of alkaloid (2.080 ± 0.000), saponin (2.080 ± 0.000) and tannin (1.040 ± 0.000). The three plants; Allium sativum, C. limon and X. aethiopica showed a significant difference in their composition of all assayed phytochemicals (P < 0.05). The inhibitory effect of plant extracts against S. aureus, E. coli and Pseudomonas spp. in all concentrations had C. limon and A. sativum as the highest while X. aethiopica showed the least inhibitory activity against Aspergillus spp. and Rhizopus spp. The study proves the effectiveness of the plant extracts in the control of human pathogens.

4 citations

Journal ArticleDOI
TL;DR: The findings in this study showed that the use of X. aethiopica may be detrimental to male reproduction function.
Abstract: Background: The uses of toxicologically unscreened plants to enhance fertility can be associated with adverse consequences. Objective: This study aimed to evaluate the effect of the ethanolic stem back extract of X. aethiopica (EEXA) on the fertility indices of male albino rats. Materials and Methods: Sixty male albino rats (weighing 200-250 gr) were grouped and administered by gavage with 200-800 mg/kg of EEXA daily for 15, 30, and 60 days. After the administration of EEXA, the rats were weighed and sacrificed. Blood samples were collected, serum samples were extracted, and evaluated for testosterone, follicle stimulating hormone, prolactin, estradiol, luteinizing hormone and progesterone levels. The testes, epididymis, and prostrate were harvested, weighed and testes were evaluated for sperm parameters. Results: Significant increase in body weight (p = 0.02) with significant decreases in testes (p = 0.01), epididymis (p = 0.01), and prostate (p = 0.02) weights occurred in rats administered with EEXA when compared to the control group. Significant (p 0.05) effects on sperm pH when compared to control. Furthermore, luteinizing hormone, follicle stimulating hormone, and testosterone levels were significantly decreased whereas serum prolactin, estradiol, and progesterone levels were significantly increased in a dose-dependent fashion in rats administered with EEXA when compared to the control group. Conclusion: The findings in this study showed that the use of X. aethiopica may be detrimental to male reproduction function. Key words: Xylopia aethiopica, Toxicity, Sperm, Hormone, Rat.

4 citations

Journal ArticleDOI
TL;DR: The essential oil from fruits, leaves and stem bark of Xylopia aethiopica of Congo-Brazzaville was obtained by steam distillation and analyzed by CG on two columns with different polarities (polar and apolar) and by CG/SM as discussed by the authors.
Abstract: The essential oil from fruits, leaves and stem bark of Xylopia aethiopica of Congo-Brazzaville was obtained by steam distillation and analyzed by CG on two columns with different polarities (polar and apolar) and by CG/SM. The essential oil from fruits was characterized by the presence of three constituents at levels of at least 10%. These were pinenes (alpha-+beta-) as major components (17%), 1, 8-cineole (13.3%) and sabinene (10%), all monoterpene hydrocarbons. The three most abundant oxygenated monoterpenes were trans-pinocarveol (8.2%), myrtenal (6.3%) and myrtenol (6.2%). The essential oil from leaves was characterized by the presence of pinenes (alpha-+beta-) as major components (39-60%). Sesquiterpenes came second, with caryophyllene the most abundant (6-18%). Oil from stem bark was made up of pinenes (27-57%), with beta-cubebene (11-14%) in second position and transpinocarveol (6%) and myrtenal (5%) jointly in third position.

4 citations

01 Jan 2015
TL;DR: In this paper, the HPTLC fingerprint in the chloroform fraction of aqueous methanol extract of xylopia aethiopica fruits was evaluated to reveal the purity, identity/structural characteristics and bioactive components of about eighty-one phytotherapeutic chemicals.
Abstract: Dried fruits of xylopia aethiopica are used in traditional system of medicine for the treatment of many diseases in Nigeria. This study evaluated the HPTLC fingerprint in the chloroform fraction of aqueous- methanol (1:4 w/w) extract of xylopia aethiopica fruits. The results revealed the purity, identity/structural characteristics and bioactive components of about eighty-one (81) phytotherapeutic chemicals consisting phytosteroid γ-Sitosterol (1%), carbohydrate (1.5%), alkaloids (22 %), flavonoids (31% ) terpenes (44.5%) , as well as fatty acids ( unsaturated, 54.3% and saturated 22.2%) and others (protein/amino acids etc., 23.5%) which have important clinical implications in determination of molecular targets and /or mechanisms of action of the physio-chemicals responsible for the various biological activities.

3 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202115
202022
201913
201828
201717
201621