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Xylopia aethiopica

About: Xylopia aethiopica is a research topic. Over the lifetime, 347 publications have been published within this topic receiving 5511 citations.


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Journal ArticleDOI
TL;DR: These findings establish the analgesic properties of the ethanol fruit extract of X. aethiopica and its major diterpene, xylopic acid as well as carrageenan-induced mechanical and thermal hyperalgesia in animals.
Abstract: Background: Fruit extracts of Xylopia aethiopica are used traditionally in the management of pain disorders including rheumatism, headache, colic pain, and neuralgia Little pharmacological data exists in scientific literature of the effect of the fruit extract and its major diterpene, xylopic acid, on pain The present study evaluated the analgesic properties of the ethanol extract of X aethiopica (XAE) and xylopic acid (XA), in murine models Materials and Methods: XAE and XA were assessed in chemical (acetic acid-induced abdominal writhing and formalin tests), thermal (Tail-flick and Hargreaves thermal hyperalgesia tests), and mechanical (Randall-Selitto paw pressure test) pain models Results: XAE and XA exhibited significant analgesic activity in all the pain models used XAE (30-300 mg kg -1 , po) and XA (10-100 mg kg -1 , po) inhibited acetic acid-induced visceral nociception, formalin- induced paw pain (both neurogenic and inflammatory), thermal pain as well as carrageenan-induced mechanical and thermal hyperalgesia in animals Morphine (1-10 mg kg -1 , ip) and diclofenac (1-10 mg kg -1 , ip), used as controls, exhibited similar anti-nociceptive activities XAE and XA did not induce tolerance to their respective anti-nociceptive effects in the formalin test after chronic administration Morphine tolerance did not also cross-generalize to the analgesic effects of XAE or XA Conclusions: These findings establish the analgesic properties of the ethanol fruit extract of X aethiopica and its major diterpene, xylopic acid

74 citations

01 Jan 2010
TL;DR: Cameroonian spices exhibit properties that are beneficial to health and could therefore be used as an alternativ e and/or complementary strategy in managing risk factors and associated co-morbidities of diabetes mellitus.
Abstract: Diabetes mellitus and associated co-morbidities i ncluding cardiovascular disease (CVD) and obesity are leading causes of mortality. In developing countries, where the per capita income is low, it is necessary to seek affordable alternative therapies. This study investigated 19 different com monly used Cameroonian spices for their polyphenol content, as well as their in v itro antioxidant, anti-amylase and anti-lipase activities. Results indicated that the aqueous extracts of Aframomum daniellii , Hypodapnis zenkeri, Echinops giganteus , Aframomum citratum , Xylopia aethiopica , had more than 75% inhibitory activity for pancrea tic amylase. Xylopia aethiopica (92.25%) and Scorodophloeus zenkeri (56.39%) were most effective in inhibiting the activity of pancreatic lipase. Dichrostachys glomerata (81.58%), Tetrapleura tetraptera (83.94%) and Xylopia parviflora (90.55%) exhibited the most potent 2, 2’-Azinobis (3-ethylbenzothiazoline-6-sul fonic acid) (ABTS + ) radical scavenging activity. These spices therefore exhibit ed properties that are beneficial to health and could therefore be used as an alternativ e and/or complementary strategy in managing risk factors and associated co-morbidities of diabetes mellitus.

72 citations

Journal ArticleDOI
TL;DR: Results indicate that XAFE could be a potential therapeutic agent against cancer since it inhibits cell proliferation, and induces apoptosis and cell cycle arrest in C‐33A cells.
Abstract: The anticancer potential of Xylopia aethiopica fruit extract (XAFE), and the mechanism of cell death it elicits, was investigated in various cell lines. Treatment with XAFE led to a dose-dependent growth inhibition in most cell lines, with selective cytotoxicity towards cancer cells and particularly the human cervical cancer cell line C-33A. In this study, apoptosis was confirmed by nuclear fragmentation and sub-G(0)/G(1) phase accumulation. The cell cycle was arrested at the G(2)/M phase with a decreased G(0)/G(1) population. A semi-quantitative gene expression study revealed dose-dependent up-regulation of p53 and p21 genes, and an increase in the Bax/Bcl-2 ratio. These results indicate that XAFE could be a potential therapeutic agent against cancer since it inhibits cell proliferation, and induces apoptosis and cell cycle arrest in C-33A cells.

68 citations

Journal ArticleDOI
TL;DR: The stem bark of Xylopia aethiopica has yielded four diterpenes, two of them novel as discussed by the authors, including (−)-kaur-16-en-19-oic acid and its 7-oxo and 7β-hydroxy derivatives.

64 citations

Journal ArticleDOI
TL;DR: X. aethiopica essential oil could be a potential source of natural and low‐cost insecticide to control storage pests and a synergic effect of the compounds was observed that restored the mortality percentage observed for the oil.
Abstract: The acute toxicity of essential oils from the whole fruit (EF) or from the fibres of the fruit (FF) of the local aromatic plants Xylopia aethiopica Dunal (Annonaceae) collected in north Cameroon was evaluated on Sitophilus zeamais adults. A concentration of 1 ml of essential oil per 100 g of maize seeds was tested to determine weevil mortality after 24 h of exposure. Under these conditions, the essential oil derived from both EF and FF of X. aethiopica led to 100% mortality. In a second step, proportions of active compounds present in the oil of both EF and FF of X. aethiopica were quantified. The toxicity of the four main compounds was tested against S. zeamais: alpha-pinene, beta-pinene, Delta-3-carene and terpinen-4-ol according to their proportion in the essential oil of the concerned plant part. beta-pinene and terpinen-4-ol were responsible for 50% of the mortality at the proportion found in EF and FF essential oils respectively. When mixed, a synergic effect of the compounds was observed that restored the mortality percentage observed for the crude oil. It appears that X. aethiopica essential oil could be a potential source of natural and low-cost insecticide to control storage pests.

62 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202115
202022
201913
201828
201717
201621