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Yellow fever

About: Yellow fever is a research topic. Over the lifetime, 3188 publications have been published within this topic receiving 69513 citations. The topic is also known as: Yellow jack & Yellow plague.


Papers
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Journal ArticleDOI
TL;DR: Cross neutralization tests indicate that Zika virus is not related to yellow fever, Hawaii dengue nor to the FA and GD VII strains of Theiler's mouse encephalomyelitis virus.
Abstract: 1. (1) The isolation of what is believed to be a hitherto unrecorded virus is described. The first isolation was made in April 1947 from the serum of a pyrexial rhesus monkey caged in the canopy of Zika Forest. The second isolation was made from a lot of A. africanus taken in January, 1948, in the same forest. The virus has been called Zika virus after the locality from where the isolations were made. 2. (2) Cross neutralization tests indicate that Zika virus is not related to yellow fever, Hawaii dengue nor to the FA and GD VII strains of Theiler's mouse encephalomyelitis virus. Neutralization tests with Zika virus and the antisera of some other viruses which are neurotropic in mice gave no evidence of any identity of these with Zika virus.

2,338 citations

Journal ArticleDOI
TL;DR: The Zika virus (ZIKV) is a mosquito-borne flavivirus related to yellow fever virus, dengue virus (DENV), and West Nile virus (WNV) and is transmitted by many Aedes spp.
Abstract: To the Editor: Zika virus (ZIKV) is a mosquito-borne flavivirus related to yellow fever virus, dengue virus (DENV), and West Nile virus (WNV). It is a single-stranded positive RNA virus (10,794-nt genome) that is closely related to the Spondweni virus and is transmitted by many Aedes spp. mosquitoes, including Ae. africanus, Ae. luteocephalus, Ae. hensilli, and Ae. aegypti. The virus was identified in rhesus monkeys during sylvatic yellow fever surveillance in the Zika Forest in Uganda in 1947 and was reported in humans in 1952 (1).

1,003 citations

Journal ArticleDOI
TL;DR: Dengue research was brought from the field into the laboratory and further progress has been made possible by work on experimental animals instead of on human volunteers, and a great deal more was learned about the basic properties of the dengue viruses.
Abstract: Summary Research on dengue in the U. S. during World War II provided the following new information of special interest to military preventive medicine: 1. Proof of the existence of multiple immunological types of dengue. 2. The long persistence of immunity to homologous types of virus under conditions precluding reenforcement of immunity by subclinical reinfection. 3. The modifications of the clinical manifestations of the disease which result from reinfection with a heterologous type of virus at various periods after the primary attack. 4. The demonstration that in areas (e.g., New Guinea) where more than one imunological type of virus is present, fevers of unknown origin, clinically not recognizable as dengue, are actually caused by the dengue viruses. 5. The demonstration that type-specific immunity to dengue is associated with neutralizing antibodies for the virus, which can be used for diagnostic and epidemiologic survey purposes. 6. The propagation of dengue virus in mice with the resulting appearance of a mutant or variant strain which could be used for active immunization. In addition to the discoveries listed above, a great deal more was learned about the basic properties of the dengue viruses. Thus was dengue research brought from the field into the laboratory and further progress has been made possible by work on experimental animals instead of on human volunteers.

924 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
2023112
2022201
202177
2020124
2019150
2018145