Topic
Zephyranthes carinata
About: Zephyranthes carinata is a research topic. Over the lifetime, 5 publications have been published within this topic receiving 73 citations.
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TL;DR: Alkaloids 6, 11, 17, and 20-23 exhibited AChE inhibitory activities with IC50 values ranging from 1.21 to 184.05 μM, and a preliminary structure-activity relationship is discussed.
Abstract: Eleven new alkaloids (1–11), classified as the 12-acetylplicamine (1), N-deformyl-seco-plicamine (2), plicamine (3–6), 4a-epi-plicamine (7), seco-plicamine (8), and lycorine (9–11) framework types, along with 15 known alkaloids (12–26) were isolated from the whole plants of Zephyranthes carinata. The structures of the new alkaloids 1–11 were established by extensive spectroscopic data interpretation. The absolute configurations of 9 and 10 were defined by single-crystal X-ray diffraction analysis. Zephycarinatines A (1), B (2), and G (7) represent the first examples of 12-acetylplicamine, N-deformyl-seco-plicamine, and 4a-epi-plicamine alkaloids, respectively. Alkaloids 6, 11, 17, and 20–23 exhibited AChE inhibitory activities with IC50 values ranging from 1.21 to 184.05 μM, and a preliminary structure–activity relationship is discussed.
24 citations
TL;DR: Two new Amaryllidaceae alkaloids, 1- O -(3-hydroxybutyryl) pancratistanin and 1-O-(3-O-β- d -glucopyranosylbutyr) pancRatistatin, were isolated from the bulbs of Zephyranthes carinata by comprehensive spectral analysis.
24 citations
TL;DR: The bulbs of Zephyranthes carinata HERB were found to contain pretazettine (I) and a new phenolic base, carinatine (II), as well as lycorine (III), galanthine (IV), and haemanthamine (V).
Abstract: The bulbs of Zephyranthes carinata HERB. (Amaryllidaceae) were found to contain pretazettine (I) and a new phenolic base, carinatine (II), as well as lycorine (III), galanthine (IV), and haemanthamine (V). Carinatine (II), C17H21NO4■, was established to be O-demethylgalanthine.
22 citations
TL;DR: In this paper, two new Amaryllidaceae alkaloids, 1- O -(3-hydroxybutyryl) pancratistanin and 1-O-(3-O-β- d -glucopyranosylbutyryl) pancreatistatin, were isolated from the bulbs of Zephyranthes carinata.
Abstract: Two new Amaryllidaceae alkaloids, 1- O -(3-hydroxybutyryl) pancratistanin and 1-O-(3-O-β- d -glucopyranosylbutyryl) pancratistatin, were isolated from the bulbs of Zephyranthes carinata . The structures of the two alkaloids were established by comprehensive spectral analysis. The cytotoxicity of these two alkaloids and pancratistatin is appraised.
5 citations