Zinc toxicity

About: Zinc toxicity is a research topic. Over the lifetime, 727 publications have been published within this topic receiving 34583 citations. The topic is also known as: zinc poisoning.

A Case of Copper Deficiency Myeloneuropathy Precipitated by Zinc Ingestion and Bariatric Surgery.

Abstract: In this report, we present a case of acquired copper deficiency which initially presented as progressive pain and numbness in the patient's lower extremities. The acquired copper deficiency is attributed to a previous bariatric surgery exacerbated by zinc toxicity. A 42-year-old female with a past medical history of type 2 diabetes mellitus, anemia, hypertension, bipolar disorder, attention deficit disorder, pulmonary embolus, fibromyalgia, migraine headaches, and chronic pain as well as a remote past surgical history of gastric bypass procedure presented with progressive pain and numbness in her lower extremities. The patient reported chronic use of zinc supplements. Clinical evaluation revealed abnormal neurologic exam consistent with a myeloneuropathy and anemia. A cervical spine MRI showed increased signal intensity primarily affecting the posterior columns from C2-C6. Laboratory studies confirmed low copper, low ceruloplasmin, and elevated zinc levels. This case is an example of acquired copper deficiency due to previous bariatric surgery exacerbated by zinc ingestion. With an increased prevalence of bariatric surgery, it is important to monitor patients postoperatively for neurologic symptoms potentially due to copper deficiency.

Effects of zinc toxicity on the structure and function of immune system in ducklings

Abstract: Objective: To investigate the influence and mechanism of zinc toxicity on the stucture and function of immune organs in ducks Methods: By establishing the pathological model of zinc toxicity in ducks, some immunological methods, light and electron microscopes were used to check the changes in the stucture and function of immune system Results: (1) The body weight of ZT group was significantly lower than that of ZC group after 3 weeks (P001) (2) Weights of thymus, the bursa of Fabricius after 2 weeks and that of spleen after 3 weeks were decresed significantly in ZT ducks (3) In 4 weeks, the G 0/G 1 phases of cell cycle of thymus, bursa of Fabricius and spleen were significantly higher and S, G 2+M phases lower in ZT group than those in ZC group (4) In ZT grop, ANAE + positive rates of T lymphocytes in peripheral blood in 2 4 weeks were significantly lower than those of ZC group (P001) (5) Compared with controls, in ZT ducks the counts of lymphocyte reduced significantly and lymphocytes lined loosly in the thymus, bursa of Fabricius and spleen histopatologically The ultrastructural observation showed that the mitochondriae in lymphocytes of the thymus, bursa of Fabricius and spleen were damaged and reticular cells consisted of many primary and secondary lysosomes as well as phagocytes in ZT ducks (6) In comparison with the control, the erythocyte C 3bR rosette rates were significantly lower and the erythrocyte ICR rosette rates were significantly higher in ZT ducks (P001) Conclusion: Zinc toxicity greatly hindered the development of immune organs, caused obvious pathological injury of immune organs, and weakened the funcion of humoral, cellular and erythrocyte immunity

Effect of intraperitoneal administration of zinc in C57/6J mice.

Abstract: Intraperitoneal administration of zinc chloride to C57/6J mice in vivo at 28 micrograms/g body weight was more lethal to the male mice and induced growth retardation in the male and female survivors. In the group of experimental survivors, the weight of the lungs were significantly decreased compared with the control animals. The inherent dangers of zinc excess is highlighted, especially with regard to the possibility of cumulative zinc toxicity.

A dry mass and zinc accumulation model of young apple tree in sand culture under zinc stress

Abstract: A sand culture experiment was conducted to build a model of the dynamic accumulation and distribution of dry matter in organs of apple trees under three zinc application levels (Zn1 0.013, Zn2 0.254 and Zn3 5.07 mg L -1 ). The dry mass and zinc accumulation of young apple tree showed a logistic model response to the date, so three rate curve equations of dry mass accumulation under different zinc application levels were built. There are little effects on the accumulation and distribution of dry matter under different zinc levels at the early growth stage, and the nutrients in roots and stems are utilized by branches and leaves for quickly growth. In the later stage of growth, the young apple tree showed a significant decrease trend in all the treatments, but the dry mass accumulation rate with the moderate zinc application was significantly higher than in other treatments. The zinc accumulation rate at different zinc levels to the date can also be simulated by logistics function with R = 0.99. The mean and max rate of zinc accumulation and the day of max rate of zinc accumulation occurrence showed the significant difference among the treatments, which was Zn1>Zn2>Zn3. The dry matter accumulation is constrained by the deficiency and excess zinc supplies at the later growth stage, and zinc toxicity is happened under the excess zinc supply. The correlation of dry mass and zinc accumulation could be fitted by y = Alnx + B (x = nutrient accumulation amount). The results could support some of the hypothesis about the zinc distribution and accumulation in apple trees. Also, they provide some foundation for decision support system of apple tree management.

Effect of zinc ion on peroxidase activity of serum in cow.

Abstract: In this study, for clarifying some possible mechanism of zinc toxicity, the effect of increasing amounts of Zn2+ ion on peroxidase activity was investigated in vitro in serum of cow. The H2O2-mediated oxidation of o-dianisidine was used to assess the peroxidase activity. Results show that after preincubation of serum with 0.2-20 mM Zn2+ concentration for 5 min, peroxidase activity was inhibited compared to the control and decreased rapidly with increasing metal concentrations. The enzyme was completely inhibited after 5 min preincubation in 30 mM Zn2+. When the preincubation of serum and Zn2+ was prolonged to 30 and 60 min, the enzymatic activity decreased more rapidly with increasing metal concentration. Extended exposure of the enzyme to lower concentrations of the metal brought about the same effect as shorter exposure to higher metal concentrations.