Topic
Zinc toxicity
About: Zinc toxicity is a research topic. Over the lifetime, 727 publications have been published within this topic receiving 34583 citations. The topic is also known as: zinc poisoning.
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TL;DR: Triethylenetetramine is a copper chelator used in the treatment of Wilson’s disease and the teratogenicity of TETA may be due at least partly through induction of zinc toxicity.
Abstract: Triethylenetetramine (TETA) is a copper chelator used in the treatment of Wilson’s disease. It is applied primarily to patients with adverse reactions to D-penicillamine (DPA) (Walshe 1973). DPA influences the metabolism of the essential trace element zinc (Klingberg et al 1976). Several adverse effects including teratogenicity may be caused by the zinc depletion. It was also suggested that the teratogenicity of TETA may be due at least partly through induction of zinc toxicity (Keen et al 1983). However, the affinity of TETA for zinc in vivo was not systematicaly investigated.
1 citations
TL;DR: In this paper, the authors describe the mechanisms of zinc toxicity in the cyanobacterium Anabaena sphaerica after eight days treatment with 10 mg L−1 ZnCl2.
Abstract: The current study describes the mechanisms of zinc toxicity in the cyanobacterium Anabaena sphaerica after eight days treatment with 10 mg L−1 ZnCl2. The application of zinc not only showed elevated accumulation of the metal inside the cells but also exhibited devastating impacts on the cell numbers, morphology, and ultrastructure of A. sphaerica. The effects of zinc on the pigments contents, oxygen evolution rate, Fv/Fm, electron transport rate, and carbohydrate content were also evaluated in A. sphaerica. Moreover, zinc adversely affected nutrient uptake and the cellular energy budget in the test cyanobacterium which in turn hampered heterocyst development and nitrogen fixation. Alongside, the cyanobacterium experienced zinc-mediated non-competitive inhibition of glutamine synthetase activity, curtailed synthesis of amino acids and proteins. Furthermore, drastically reduced total lipid and increased unsaturated lipid contents were also the prominent characteristics of zinc stressed A. sphaerica. Most importantly, zinc stress caused severe damages to the protein, lipid, and DNA by triggering hydrogen peroxide generation and accumulation of oxidized glutathione. Therefore, excess zinc is highly toxic to the cyanobacterium A. sphaerica, and the mechanisms of its toxicity followed a cascade of events including oxidative stress mediated geopardisation of growth and ultrastructure, metabolic derangements, and macromolecular damages.
1 citations
TL;DR: Rats having received drinking water enriched with zinc developed significantly more pulmonal metastases after an i.v. injection of 5 x 10(5) cultivated cells of a benzpyrene-induced sarcoma than receiving normal drinking water.
Abstract: Rats having received drinking water enriched with zinc (zinc acetate, 22.8 mmol/l) developed significantly more pulmonal metastases after an i.v. injection of 5 x 10(5) cultivated cells of a benzpyrene-induced sarcoma than receiving normal drinking water. Zinc ions seem to promote the emigration, implantation and outgrowth of circulating tumour cells.
1 citations
Journal Article•
TL;DR: Seedling growth rather than seed germination appears to be the sensitive stage for both tree species when treated with copper and zinc as compared to control, and tolerance against zinc was higher asCompared to copper.
Abstract: A significant (p<0.05) reduction in seed germination due to copper toxicity at 800 ppm was observed in A. lebbeck and L. leucocephala. A significant (p<0.05) effect on root length in A. lebbeck was observed at 500 ppm of copper treatment as compared to similar concentration of zinc treatment. Higher concentration of zinc element also decreased the seedling dry weight at 1100 ppm treatment in A. lebbeck and L. leucocephala. Shoot length of L. leucocephala was more affected by copper treatment at 1100 ppm as compared to same concentration of zinc. The lower dose of copper at 200 ppm was found effective in decreasing the seedling growth of L. leucocephala and A. lebbeck. Seedling growth rather than seed germination appears to be the sensitive stage for both tree species when treated with copper and zinc as compared to control. L. leucocephala was highly affected to copper and zinc toxicity, while A. lebbeck was less affected. According to tolerance test it was found that tolerance against zinc was higher as compared to copper.
1 citations