Topic
Zinc toxicity
About: Zinc toxicity is a research topic. Over the lifetime, 727 publications have been published within this topic receiving 34583 citations. The topic is also known as: zinc poisoning.
Papers published on a yearly basis
Papers
More filters
TL;DR: ZnO-NPs cytotoxic potential was greater than those of bulk ZnO and Zn(2+) ions and induced oxidative stress is dependent on their dose, while particle dissolution did not appear to play an important role in the observed toxicity.
63 citations
TL;DR: The unified zinc BLM, developed by objectively averaging the biotic ligand binding constants for zinc and competing cations from existing BLMs, performed better in predicting toxicity to a diverse set of organisms than any individual existing BLM.
Abstract: The United States Environmental Protection Agency's (U.S. EPA) current ambient water quality criteria (AWQC) for zinc in freshwater are hardness-based and were last updated in 1995. The acute and chronic freshwater toxicity databases have since expanded substantially and the U.S. EPA's minimum phylogenetic diversity requirements for chronic zinc toxicity are now met (an acute:chronic ratio was previously required). Additionally, several acute and chronic biotic ligand models (BLMs) for zinc have since been developed and validated for freshwater organisms. Using the expanded toxicity database and existing BLMs, we developed a unified zinc BLM that could efficiently predict both acute and chronic toxicity over a wide range of zinc bioavailabilities. The unified BLM, developed by objectively averaging the biotic ligand binding constants for zinc (Zn2+) and competing cations (Ca2+, Mg2+, Na+, H+) from existing BLMs, performed better in predicting toxicity to a diverse set of organisms than any individual existing BLM. Performance of the unified BLM was further improved by optimizing the biotic ligand binding constant for the ZnOH+ species. The updated freshwater zinc toxicity database and unified BLM were then used to estimate the fifth percentiles of the acute and chronic species sensitivity distributions following the U.S. EPA guidelines for AWQC development. Environ. Toxicol. Chem. 2012;31:1264–1272. © 2012 SETAC
63 citations
TL;DR: The environmental relevance of using toxicity data obtained with organisms (natural, as well as laboratory clones) acclimated to culture media containing no or very small amounts of zinc can be questioned.
63 citations
TL;DR: Three transporters and a periplasmic protein regulated by the BaeSR two-component system are involved in zinc detoxification based on the growth defects at high cell density and increases in free and total zinc/copper after zinc shock.
Abstract: Intracellular zinc homeostasis is regulated by an extensive network of transporters, ligands and transcription factors. The zinc detoxification functions of three transporters and a periplasmic protein regulated by the BaeSR two-component system were explored in this work by evaluating the effect of single gene knockouts in the BaeSR regulon on the cell growth rate, free zinc, total zinc and total copper after zinc shock. Two exporters, MdtABC and MdtD, and the periplasmic protein, Spy, are involved in zinc detoxification based on the growth defects at high cell density and increases in free (>1000-fold) and total zinc/copper (>2-fold) that were observed in the single knockout strains upon exposure to zinc. These proteins complement the ATP-driven zinc export mediated by ZntA in E. coli to limit zinc toxicity. These results highlight the functions of the BaeSR regulon in metal homeostasis.
62 citations
TL;DR: It is demonstrated that a new fluorescent stain for zinc can rather selectively and quite vividly label zinc-filled neurons in frozen histologic sections, more sensitive and selective than the existing stain TSQ, and simpler than the Timm-Danscher silver staining techniques.
62 citations