Topic
Zinc toxicity
About: Zinc toxicity is a research topic. Over the lifetime, 727 publications have been published within this topic receiving 34583 citations. The topic is also known as: zinc poisoning.
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39 citations
TL;DR: It was found that cell growth of zrc1Delta mutant was lowered under the metal-limited conditions, which was restored by zinc, implying an important role of Zrc1 in the zinc-starvation stress.
38 citations
TL;DR: The IPEC-J2 cell line appears to be a suitable in vitro model to characterize specific effects on porcine intestinal cells and zinc sulfate induced Hsp70 mRNA expression at 200μM and was more pronounced in preconfluent cells.
38 citations
TL;DR: Evidence is outlined supporting the hypothesis that protozoan predation and macrophage killing are also responsible for selection of copper/zinc resistance genes in bacteria and the “copper pathogenicity island” identified in Escherichia coli and Salmonella strains isolated from copper- and zinc-fed Danish pigs.
Abstract: The presence of metal resistance determinants in bacteria usually is attributed to geological or anthropogenic metal contamination in different environments or associated with the use of antimicrobial metals in human healthcare or in agriculture. While this is certainly true, we hypothesize that protozoan predation and macrophage killing are also responsible for selection of copper/zinc resistance genes in bacteria. In this review, we outline evidence supporting this hypothesis, as well as highlight the correlation between metal resistance and pathogenicity in bacteria. In addition, we introduce and characterize the "copper pathogenicity island" identified in Escherichia coli and Salmonella strains isolated from copper- and zinc-fed Danish pigs.
38 citations
TL;DR: Four amino acids, which are a subset of the 15 present in Dulbecco's modified Eagle medium, were found to collectively prevent zinc toxicity, and Histidine was the most protective, followed by cystine, glutamine, and threonine.
38 citations