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Zinc toxicity

About: Zinc toxicity is a research topic. Over the lifetime, 727 publications have been published within this topic receiving 34583 citations. The topic is also known as: zinc poisoning.


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Journal ArticleDOI
TL;DR: It is demonstrated that interactions between light intensity and zinc need to be considered when studying the bloom dynamics of cyanobacteria in freshwater ecosystems.

28 citations

Journal ArticleDOI
TL;DR: The aim of this study was to identify the intrinsic molecular species that endow prostate cells with the ability to overcome zinc toxicity.
Abstract: BACKGROUND The prostate contains extremely high concentrations of zinc, which may be required for male reproduction. Although zinc is essential for many cellular functions, excessive zinc induces cellular toxicity in general. However, despite exposure to high zinc environment, prostate cells survive and proliferate. Thus, the aim of this study was to identify the intrinsic molecular species that endow prostate cells with the ability to overcome zinc toxicity. METHODS Immunohistochemistry, histofluorescent zinc staining, Western blot, in vitro binding assay, immunoprecipitation, caspase activity assay, and proteasome activity assay. RESULTS In rat and human prostates, HIF-1α was found to be robustly expressed in epithelial layers containing high zinc levels. Moreover, in cultured prostate cells, HIF-1α expression was zinc-dependently induced even under normoxic conditions. Mechanistically, zinc ions inhibited HIF-1-prolyl hydroxylase (PHD) activity, and therefore blocked von Hippel-Lindau tumor suppressor protein (pVHL) binding to HIF-1α in vivo and in vitro. The HIF-1α stabilization was mediated by oxidative stress induced by zinc ion. Even when prostate cells were treated with high concentrations of zinc ion for extended times, only 10% of cells showed apoptotic death. However, this population of apoptotic cells was increased threefold after HIF-1α was knocked-down by siRNA. CONCLUSION These results suggest that HIF-1α functions as an intrinsic defense molecule that enables prostate cells to survive in a zinc-rich environment. Prostate 67: 1514–1523, 2007. © 2007 Wiley-Liss, Inc.

28 citations

Journal ArticleDOI
TL;DR: Copper- and zinc-containing welding fumes are able to induce systemic inflammation in humans as shown by an increase of blood C-reactive protein.
Abstract: Objective Recently, it has been shown that exposure to welding fumes containing both zinc and copper leads to asymptomatic systemic inflammation in humans as shown by an increase of blood C-reactive protein. In the present study, it was investigated which metal is responsible for this effect. Methods Fifteen healthy male subjects were exposed under controlled conditions to welding fumes containing either zinc, or copper, or copper and zinc. Results For each exposure blood C-reactive protein increased. Conclusions Copper- and zinc-containing welding fumes are able to induce systemic inflammation.

28 citations

Journal ArticleDOI
TL;DR: This study confirms the higher susceptibility of L. sativa to Zn stress: lettuce plants experienced a strong reduction in biomass, while the levels of Pro and GB increased, suggesting that reactive oxygen species detoxification could be essential to improve the resistance to toxicity under metal stress conditions.
Abstract: Zinc (Zn) pollution in the soil represents a major problem for crop production worldwide. In the present work, two horticultural plants exhibiting different tolerance to Zn, Lactuca sativa cv. Phillipus and Brassica oleracea cv. Bronco, were exposed to Zn to evaluate the contribution of compatible osmolytes such as proline (Pro), glycine betaine (GB) and γ-aminobutyric acid (GABA) in the mechanism(s) of tolerance to Zn stress. This study confirms the higher susceptibility of L. sativa to Zn stress: lettuce plants experienced a strong reduction in biomass, while the levels of Pro and GB increased. These results suggest that in L. sativa, the increase of Pro and GB does not represent a mechanism of resistance to toxicity, but it is likely a symptom of Zn stress. Conversely, in B. oleracea, a slight decrease in Pro levels, mainly catalysed by degradation through proline dehydrogenase, was observed; a similar behaviour affected GB levels. On the other hand, GABA synthesis was slightly, but significantly, increased. The presence of high levels of GABA in Zn-stressed B. oleracea would suggest that reactive oxygen species detoxification could be essential to improve the resistance to toxicity under metal stress conditions.

27 citations


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Performance
Metrics
No. of papers in the topic in previous years
YearPapers
202312
202221
202114
202021
201917
201818