M
Mireia Coscolla
Researcher at University of Valencia
Publications - 67
Citations - 4446
Mireia Coscolla is an academic researcher from University of Valencia. The author has contributed to research in topics: Mycobacterium tuberculosis & Mycobacterium tuberculosis complex. The author has an hindex of 28, co-authored 64 publications receiving 3613 citations. Previous affiliations of Mireia Coscolla include Swiss Tropical and Public Health Institute & University of Basel.
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Journal ArticleDOI
Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans
Iñaki Comas,Mireia Coscolla,Mireia Coscolla,Tao Luo,Sonia Borrell,Sonia Borrell,Kathryn E. Holt,Midori Kato-Maeda,Julian Parkhill,Bijaya Malla,Bijaya Malla,Stefan Berg,Guy E. Thwaites,Dorothy Yeboah-Manu,Graham H. Bothamley,Jian Mei,Lan-Hai Wei,Stephen D. Bentley,Simon R. Harris,Stefan Niemann,Roland Diel,Abraham Aseffa,Qian Gao,Douglas B. Young,Douglas B. Young,Sebastien Gagneux,Sebastien Gagneux +26 more
TL;DR: Coalescent analyses indicate that MTBC emerged about 70,000 years ago, accompanied migrations of anatomically modern humans out of Africa and expanded as a consequence of increases in human population density during the Neolithic period, consistent with MTBC displaying characteristics indicative of adaptation to both low and high host densities.
Journal ArticleDOI
Pre-Columbian mycobacterial genomes reveal seals as a source of New World human tuberculosis
Kirsten I. Bos,Kelly M. Harkins,Alexander Herbig,Mireia Coscolla,Nico Weber,Iñaki Comas,Stephen Forrest,Josephine M. Bryant,Simon R. Harris,Verena J. Schuenemann,Tessa J. Campbell,Kerttu Majander,Alicia K. Wilbur,Ricardo Aníbal Guichón,Dawnie Wolfe Steadman,Della Collins Cook,Stefan Niemann,Marcel A. Behr,Martín José Zumárraga,Ricardo Bastida,Daniel H. Huson,Kay Nieselt,Douglas B. Young,Julian Parkhill,Jane E. Buikstra,Sebastien Gagneux,Anne C. Stone,Johannes Krause +27 more
TL;DR: Three 1,000-year-old mycobacterial genomes from Peruvian human skeletons are presented, revealing that a member of the M. tuberculosis complex caused human disease before contact and implicate sea mammals as having played a role in transmitting the disease to humans across the ocean.
Journal ArticleDOI
Consequences of genomic diversity in Mycobacterium tuberculosis.
TL;DR: Overall, the most geographically widespread Lineage 2 and Lineage 4 are more virulent than other lineages that are more geographically restricted and are associated with delayed or reduced pro-inflammatory host immune responses, greater severity of disease, and enhanced transmission.
Journal ArticleDOI
Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages.
David Stucki,David Stucki,Daniela Brites,Daniela Brites,Leïla Jeljeli,Mireia Coscolla,Mireia Coscolla,Qingyun Liu,Andrej Trauner,Andrej Trauner,Lukas Fenner,Lukas Fenner,Lukas Fenner,Liliana K. Rutaihwa,Liliana K. Rutaihwa,Sonia Borrell,Sonia Borrell,Tao Luo,Qian Gao,Midori Kato-Maeda,Marie Ballif,Marie Ballif,Marie Ballif,Matthias Egger,Rita Macedo,Helmi Mardassi,Milagros Moreno,Griselda Tudo Vilanova,Janet A. M. Fyfe,Maria Globan,Jackson Thomas,Frances B. Jamieson,Jennifer L. Guthrie,Adwoa Asante-Poku,Dorothy Yeboah-Manu,Eddie M. Wampande,Willy Ssengooba,Willy Ssengooba,Moses Joloba,W. Henry Boom,Indira Basu,James E. Bower,Margarida Saraiva,Sidra Ezidio Gonçalves Vasconcellos,Philip Noel Suffys,Anastasia Koch,Robert J. Wilkinson,Robert J. Wilkinson,Robert J. Wilkinson,Linda Gail-Bekker,Bijaya Malla,Bijaya Malla,Serej D. Ley,Serej D. Ley,Serej D. Ley,Hans-Peter Beck,Hans-Peter Beck,Bouke C. de Jong,Kadri Toit,Elisabeth Sanchez-Padilla,Maryline Bonnet,Ana Gil-Brusola,Matthias Frank,Véronique Penlap Beng,Kathleen D. Eisenach,Issam Alani,Perpetual Wangui Ndung'u,Gunturu Revathi,Florian Gehre,Florian Gehre,Suriya Akter,Francine Ntoumi,Lynsey Stewart-Isherwood,Nyanda E. Ntinginya,Andrea Rachow,Michael Hoelscher,Daniela Maria Cirillo,Girts Skenders,Sven Hoffner,Daiva Bakonyte,Petras Stakenas,Roland Diel,Valeriu Crudu,Olga Domnica Moldovan,Sahal Al-Hajoj,Larissa Otero,Francesca Barletta,E. Jane Carter,E. Jane Carter,Lameck Diero,Philip Supply,Iñaki Comas,Stefan Niemann,Sebastien Gagneux,Sebastien Gagneux +94 more
TL;DR: It is shown that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists, and further support a European origin for the most common generalist sublineage.
Journal ArticleDOI
Acquired Resistance to Bedaquiline and Delamanid in Therapy for Tuberculosis
Guido V. Bloemberg,Peter M. Keller,David Stucki,Andrej Trauner,Sonia Borrell,Tsogyal D. Latshang,Mireia Coscolla,Thomas Rothe,Rico Hömke,Claudia Ritter,Julia Feldmann,Bettina Schulthess,Sebastien Gagneux,Erik C. Böttger +13 more
TL;DR: This letter describes the emergence of resistance to new therapies, bedaquiline and delamanid, in multidrug-resistant Mycobacterium tuberculosis.