Shelby L. O’Connor

TL;DR: It is shown that rhesus macaques are susceptible to infection by an Asian-lineage ZIKV closely related to strains currently circulating in the Americas, and provides a relevant animal model for studying pathogenesis and evaluating potential interventions against human infection, including during pregnancy.

TL;DR: Cross-species transmission of simian immunodeficiency virus from sooty mangabeys into rhesus macaques, and subsequent emergence of pathogenic SIVmac, required adaptation to overcome restriction encoded by the macaque TRIM5 gene.

TL;DR: The results may suggest that maternal-fetal ZIKV transmission in human pregnancy may be more frequent than currently appreciated and assess risk factors and test therapeutic interventions for interruption of fetal infection.

TL;DR: Microsatellite analysis is used to show that simian immunodeficiency virus-susceptible cynomolgus macaques from the Indian Ocean island of Mauritius have extremely simple MHC genetics, with six common haplotypes accounting for two-thirds of the MHC haplotypes in feral animals.

TL;DR: These findings show that primary MM cells frequently harbor PIR NF-κB activity that is further enhanced by the presence of patient-derived BMSCs, and suggest that this activity is likely relevant to the drug resistance development in some patients.