Revealing fine-scale spatiotemporal differences in SARS-CoV-2 introduction and spread.
Gage K. Moreno,Katarina M. Braun,Kasen K. Riemersma,Michael A. Martin,Peter Halfmann,Chelsea M. Crooks,Trent M. Prall,David Baker,John J. Baczenas,Anna S. Heffron,Mitchell D. Ramuta,Manjeet Khubbar,Andrea M. Weiler,Molly A. Accola,William M. Rehrauer,Shelby L. O’Connor,Nasia Safdar,Caitlin S. Pepperell,Trivikram Dasu,Sanjib Bhattacharyya,Yoshihiro Kawaoka,Katia Koelle,David H. O’Connor,Thomas C. Friedrich +23 more
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Analysis of 247 full-genome SARS-CoV-2 sequences from two nearby communities in Wisconsin, USA finds surprisingly distinct patterns of viral spread, which suggest patterns of Sars-Cov-2 transmission may vary substantially even in nearby communities.Abstract:
Evidence-based public health approaches that minimize the introduction and spread of new SARS-CoV-2 transmission clusters are urgently needed in the United States and other countries struggling with expanding epidemics. Here we analyze 247 full-genome SARS-CoV-2 sequences from two nearby communities in Wisconsin, USA, and find surprisingly distinct patterns of viral spread. Dane County had the 12th known introduction of SARS-CoV-2 in the United States, but this did not lead to descendant community spread. Instead, the Dane County outbreak was seeded by multiple later introductions, followed by limited community spread. In contrast, relatively few introductions in Milwaukee County led to extensive community spread. We present evidence for reduced viral spread in both counties following the statewide "Safer at Home" order, which went into effect 25 March 2020. Our results suggest patterns of SARS-CoV-2 transmission may vary substantially even in nearby communities. Understanding these local patterns will enable better targeting of public health interventions.read more
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Acute SARS-CoV-2 infections harbor limited within-host diversity and transmit via tight transmission bottlenecks.
Katarina M. Braun,Gage K. Moreno,Cassia Wagner,Molly A. Accola,William M. Rehrauer,David A. Baker,Katia Koelle,David H. O’Connor,Trevor Bedford,Thomas C. Friedrich,Louise H. Moncla +10 more
TL;DR: The authors found that within-host diversity is low and transmission bottlenecks are narrow, with very few viruses founding most infections, and most variation generated within host is lost during transmission.
Journal ArticleDOI
Phylogenetic and phylodynamic approaches to understanding and combating the early SARS-CoV-2 pandemic
TL;DR: In this paper , the authors describe how phylogenetic and phylodynamic methods provide insight into viral evolution, focusing on the SARS-CoV-2 pandemic, and summarize their contributions to our understanding of SARS transmission and control.
Journal ArticleDOI
Viral Sequencing to Investigate Sources of SARS-CoV-2 Infection in US Healthcare Personnel.
Katarina M. Braun,Gage K. Moreno,Ashley Buys,Elizabeth D Somsen,Max Bobholz,Molly A. Accola,Laura Anderson,William M. Rehrauer,David A. Baker,Nasia Safdar,Alexander J. Lepak,David H. O’Connor,Thomas C. Friedrich +12 more
TL;DR: In this paper, the authors investigated the likely source of SARS-CoV-2 infection in healthcare personnel (HCP) at a major academic medical institution in the Upper Midwest of the United States between 25 March - 27 December, 2020.
Journal ArticleDOI
SARS-CoV-2 Genomic Surveillance Reveals Little Spread From a Large University Campus to the Surrounding Community.
Andrew L Valesano,William J. Fitzsimmons,Christopher N. Blair,Robert J. Woods,Julie Gilbert,Dawn Rudnik,Lindsey Mortenson,Thomas C. Friedrich,David H. O’Connor,Duncan MacCannell,Joshua G. Petrie,Emily T. Martin,Adam S. Lauring +12 more
TL;DR: In this paper, the authors implemented high-density prospective genomic surveillance to investigate the dynamics at the University of Michigan and the surrounding community during the Fall 2020 semester (August 16-November 24).
Journal ArticleDOI
Interventions to Disrupt Coronavirus Disease Transmission at a University, Wisconsin, USA, August-October 2020.
Dustin W Currie,Gage K. Moreno,Miranda J Delahoy,Ian W Pray,Amanda Jovaag,Katarina M. Braun,Devlin Cole,Todd Shechter,Geroncio C Fajardo,Carol A Griggs,Brian S. Yandell,Steve Goldstein,Dena Bushman,Hannah E Segaloff,G. Patrick Kelly,Collin Pitts,Christine M. Lee,Katarina M. Grande,Amanda Kita-Yarbro,Brittany E. Grogan,Sara Mader,Jake Baggott,Allen C. Bateman,Ryan P. Westergaard,Jacqueline E. Tate,Thomas C. Friedrich,Hannah L Kirking,David H. O’Connor,Marie E Killerby +28 more
TL;DR: In this article, the authors describe a COVID-19 outbreak at the University of Wisconsin-Madison, Madison, Wisconsin, USA during August-October 2020, a total of 3,485 students, including 856/6,162 students living in dormitories, tested positive.
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