https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(09)60829-1.pdf

Human African trypanosomiasis

During the 1930s and 1940s the idea of releasing insects of pest species to introduce sterility (sterile insect technique or SIT) into wild populations, and thus control them, was independently conceived in three extremely diverse intellectual environments. The key researchers were A. S. Serebrovskii at Moscow State University, F. L. Vanderplank at a tsetse field research station in rural Tanganyika (now Tanzania), and E. F. Knipling of the United States Department of Agriculture. Serebrovskii’s work on chromosomal translocations for pest population suppression could not succeed in the catastrophic conditions in the USSR during World War II, after which he died. Vanderplank used hybrid sterility to suppress a tsetse population in a large field experiment, but lacked the resources to develop this method further. Knipling and his team exploited H. J. Muller’s discovery that ionizing radiation can induce dominant lethal mutations, and after World War II this approach was applied on an area-wide basis to eradicate the New World screwworm Cochliomyia hominivorax (Coquerel) in the USA, Mexico, and Central America. Since then very effective programmes integrating the SIT have been mounted against tropical fruit flies, some species of tsetse flies Glossina spp., the pink bollworm Pectinophora gossypiella (Saunders), and the codling moth Cydia pomonella (L.). In non-isolated onion fields in the Netherlands, the onion maggot Delia antiqua (Meigen) has since 1981 been suppressed by the SIT. In the 1970s there was much research conducted on mosquito SIT, which then went into “eclipse”, but now appears to be reviving. Development of the SIT for use against the boll weevil Anthonomus grandis grandis Boheman and the gypsy moth Lymantria dispar (L.) has ended, but it is in progress for two sweetpotato weevil species, Cylas formicarius (F.) and Euscepes postfasciatus (Fairmaire), the false codling moth Cryptophlebia leucotreta (Meyrick), the carob moth Ectomyelois ceratoniae (Zeller), the cactus moth Cactoblastis cactorum (Berg), the Old World screwworm Chrysomya bezziana (Villeneuve), additional Glossina spp., other Anastrepha spp. and Bactrocera spp. fruit flies, and other pest insects.

History of the Sterile Insect Technique

While the number of new detected cases of HAT is falling, say the authors, sleeping sickness could suffer the "punishment of success," receiving lower priority by public and private health institutions.

/pdf/eliminating-human-african-trypanosomiasis-where-do-we-stand-56xfzdpl94.pdf

Eliminating human African trypanosomiasis: where do we stand and what comes next?

The prehistory of African trypanosomiasis indicates that the disease may have been an important selective factor in the evolution of hominids. Ancient history and medieval history reveal that African trypanosomiasis affected the lives of people living in sub-Saharan African at all times. Modern history of African trypanosomiasis revolves around the identification of the causative agents and the mode of transmission of the infection, and the development of drugs for treatment and methods for control of the disease. From the recent history of sleeping sickness we can learn that the disease can be controlled but probably not be eradicated. Current history of human African trypanosomiasis has shown that the production of anti-sleeping sickness drugs is not always guaranteed, and therefore, new, better and cheaper drugs are urgently required.

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The history of African trypanosomiasis

Publisher Summary This chapter describes sterile insect techniques (SIT). It is a biologically based method for the control of key insect pests. Wild female insects inseminated by released, radiation-sterilized males do not reproduce, and repeated releases of the sterilized insects lead to a reduction in pest population numbers. Effective control using sterile insects is achieved when they are used systematically as part of area-wide integrated pest management (AW-IPM) programs. SIT is species-specific, nonpolluting, and resistance-free. Since the original concept was developed in the United States in the 1940s, SIT has been used successfully for screwworm flies, tsetse flies, fruit flies, and moths. Technical progress in behavioral ecology, mass rearing, strain improvement, global information, positioning and monitoring systems, and aerial release, combined with economies of scale and a growing demand for pest-free and low-pesticide agricultural products in local and international trade, have increased the use of SIT in AW-IPM programs. These programs, by decreasing insecticide use, have also facilitated the use of biological control agents against secondary insect pests.

/pdf/sterile-insect-technique-xi6er5rwhs.pdf

Sterile Insect Technique

An area-wide integrated tsetse eradication project was initiated in Zanzibar in 1994 by the International Atomic Energy Agency and the governments of Tanzania and Zanzibar, to eradicate Glossina austeni Newstead from Unguja Island (Zanzibar) using the sterile insect technique. Suppression of the tsetse population on Unguja was initiated in 1988 by applying residual pyrethroids as a pour-on formulation to livestock and by the deployment of insecticide impregnated screens in some of the forested areas. This was followed by sequential releases of gamma-sterilized male flies by light aircraft. The flies, packaged in carton release containers, were dispersed twice a week along specific flight lines separated by a distance of 1–2 km. More than 8.5 million sterile male flies were released by air from August 1994 to December 1997. A sterile to indigenous male ratio of >50:1 was obtained in mid-1995 and it increased to >100:1 by the end of 1995. As a consequence the proportion of sampled young females (1–2 ovulations), with an egg in utero in embryonic arrest or an uterus empty as a result of expulsion of a dead embryo, increased from 70% in the last quarter of 1995. In addition, the age structure of the female population became significantly distorted in favor of old flies (≥4 ovulations) by the end of 1995. The apparent density of the indigenous fly population declined rapidly in the last quarter of 1995, followed by a population crash in the beginning of 1996. The last trapped indigenous male and female flies were found in weeks 32 and 36, 1996, respectively. Time for 6 fly generations elapsed between the last catch of an indigenous fly and the end of the sterile male releases in December 1997.

https://bioone.org/journals/journal-of-economic-entomology/volume-93/issue-1/0022-0493-93.1.123/Glossina-austeni-Diptera--Glossinidae-Eradicated-on-the-Island-of/10.1603/0022-0493-93.1.123.pdf

Glossina austeni (Diptera: Glossinidae) eradicated on the island of Unguja, Zanzibar, using the sterile insect technique.

1Insect Pest Control Laboratory, Joint FAO/IAEA Programme of Nuclear Techniques in Food and Agriculture, Vienna, Austria, 2Ministry of Agriculture, Natural Resourcesand Environment, Zanzibar, Tanzania, 3Vector and Vector Borne Diseases Research Institute, Tanga, Tanzania, 4Insect Pest Control Section, Joint FAO/IAEA Programme ofNuclear Techniques in Food and Agriculture, Vienna, Austria, 5Retired, Independent Researcher, Vienna, Austria, 6Livestock Research, Training & Extension, Ministry ofLivestock & Fisheries Development, Dar es Salaam, Tanzania, 7Unite´ Mixte de Recherche Controˆle des Maladies Animales Exotiques et Emergentes, Centre de Coope´rationInternationale en Recherche Agronomique pour le De´veloppement (CIRAD), Montpellier, France, 8Unite´ Mixte de Recherche 1309 Controˆle des Maladies AnimalesExotiques et Emergentes, Institut national de la recherche agronomique (INRA), Montpellier, France, 9Institut Se´ne´galais de Recherches Agricoles, Laboratoire Nationald’Elevage et de Recherches Ve´te´rinaires, Dakar-Hann, Se´ne´gal

/pdf/sterile-insects-to-enhance-agricultural-development-the-case-582epv6puz.pdf

Sterile insects to enhance agricultural development: the case of sustainable tsetse eradication on Unguja Island, Zanzibar, using an area-wide integrated pest management approach.

Atway R. Msangi

Papers

Glossina austeni (Diptera: Glossinidae) eradicated on the island of Unguja, Zanzibar, using the sterile insect technique.

Sterile insects to enhance agricultural development: the case of sustainable tsetse eradication on Unguja Island, Zanzibar, using an area-wide integrated pest management approach.