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Bruce R. Gelin
Researcher at Harvard University
Publications - 10
Citations - 3067
Bruce R. Gelin is an academic researcher from Harvard University. The author has contributed to research in topics: Protein structure & Tetramer. The author has an hindex of 8, co-authored 10 publications receiving 2935 citations.
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Dynamics of folded proteins
TL;DR: The dynamics of a folded globular protein have been studied by solving the equations of motion for the atoms with an empirical potential energy function and suggest that the protein interior is fluid-like in that the local atom motions have a diffusional character.
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The hinge-bending mode in lysozyme
TL;DR: A theoretical study of a low frequency vibration involving the two globular lobes of lysozyme between which the cleft containing the active site is located and finds that any motion involving this cleft could play a part in the catalytic activity.
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Side-chain torsional potentials: effect of dipeptide, protein, and solvent environment.
Bruce R. Gelin,Martin Karplus +1 more
TL;DR: The results are discussed in terms of the details of the interactions due to the surrounding, calculated solvent-accessibility figures and the temperature factors derived from the crystallographic refinement of the pancreatic trypsin inhibitor.
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Mechanism of tertiary structural change in hemoglobin.
Bruce R. Gelin,Martin Karplus +1 more
TL;DR: A reaction path is presented by which the effects of oxygen binding in hemoglobin are transmitted from a heme group to the surface of its subunit, and it is found that there is little strain on the unliganded heme.
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Sidechain torsional potentials and motion of amino acids in porteins: bovine pancreatic trypsin inhibitor
Bruce R. Gelin,Martin Karplus +1 more
TL;DR: To estimate the effective barriers for rotation of the aromatic rings (tyrosine and phenylalanine), calculations are done in which the protein is permitted to relax as a function of the ring orientation, resulting barriers are much lowere than the rigid rotation barriers.