K
Ken Yasui
Researcher at Tohoku University
Publications - 16
Citations - 554
Ken Yasui is an academic researcher from Tohoku University. The author has contributed to research in topics: Enantioselective synthesis & Alkylation. The author has an hindex of 9, co-authored 16 publications receiving 537 citations.
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Journal ArticleDOI
Highly selective and orally active inhibitors of type IV collagenase (MMP-9 and MMP-2): N-sulfonylamino acid derivatives.
Yoshinori Tamura,Fumihiko Watanabe,Takuji Nakatani,Ken Yasui,Masahiro Fuji,Tadafumi Komurasaki,Tsuzuki Hiroshige,Ryuji Maekawa,Yoshioka Takayuki,Kenji Kawada,Kenji Sugita,Mitsuaki Ohtani +11 more
TL;DR: A series of aryl sulfonamide derivatives containing biaryl, tetrazole, amide, and triple bond were found to be potent and highly selective inhibitors of M MP-9 and MMP-2.
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Total synthesis of (-)-PA-48153C, a novel immunosuppressive 2-pyranone derivative
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Enantioselective construction of a quaternary asymmetric carbon center: a versatile synthesis of .alpha.-alkyl .alpha.-amino acids
Masataka Ihara,Masanobu Takahashi,Hiroko Niitsuma,Nobuaki Taniguchi,Ken Yasui,Keiichiro Fukumoto +5 more
TL;DR: Alkylation enantioselective des dianions derives des monoesters chiraux d'acides maloniques monosubstitues avec des halogenures d'alkyles as discussed by the authors.
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Asymmetric total synthesis of(–)-protoemetinol,(–)-protoemetine,(–)-emetine, and (–)-tubulosine by highly stereocontrolled radical cyclisations
TL;DR: Both enantiomers of the menthyl halfesters (10) and (23) of ethylmalonic acid were converted into (+)-(4S,5R)-4-(2-benzyloxyethyl)-5-ethyl-3,4,5,6-tetrahydro-2-pyrone (18) as discussed by the authors.
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Chemical Modification of PA-48153C, a Novel Immunosuppressant Isolated from Streptomyces prunicolor PA-48153.
Ken Yasui,Yoshinori Tamura,Takuji Nakatani,Isao Horibe,Kenji Kawada,Kenzo Koizumi,Ryuji Suzuki,Mitsuaki Ohtani +7 more
TL;DR: Among them, the C-8 hexanoate 28 showed potent suppressive effects on mitogen responses with less cytotoxicity to EL4 cells and was selected for in vivo evaluation.