M
M. Mergler
Publications - 6
Citations - 307
M. Mergler is an academic researcher. The author has contributed to research in topics: Peptide synthesis & Benzyl alcohol. The author has an hindex of 6, co-authored 6 publications receiving 304 citations.
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Peptide synthesis by a combination of solid-phase and solution methods. I: A new very acid-labile anchor group for the solid phase synthesis of fully protected fragments
TL;DR: In this article, the synthesis of a new polymeric support for the preparation of fully protected peptide fragments by the Fmoc/t-butyl method is described, and data for coupling yields and racemization data are given.
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Peptide synthesis by a combination of solid-phase and solution methods II synthesis of fully protected peptide fragments on 2-methoxy-4-alkoxy-benzyl alcohol resin
TL;DR: In this paper, the synthesis of fully protected peptide fragments by the Fmoc/ t-butyl method on a new polymeric support is described, which is obtained in good yields and high purity upon cleavage from the resin with 0.5 - 1 % trifluoroacetic acid in methylene chloride.
Journal ArticleDOI
Peptide synthesis by a combination of solid-phase and solution methods III resin derivatives allowing minimum-racemization coupling of nα-protected amino acids
M. Mergler,R. Nyfeler,J. Gosteli +2 more
TL;DR: In this article, the conversion of 4-alkoxy benzyl alcohol resin and 2-methoxy-4-alkoxal alcohol resin (SASRIN) into the corresponding halides is described.
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Solid phase synthesis of fully protected peptide alcohols
TL;DR: In this paper, a mild and efficient method to obtain fully t-butyl type protected alcohols based on the alkylation of Fmoc amino alcohols with the polymeric diphenyldiazomethane was presented.
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Peptide synthesis by a combination of solid-phase and solution methods IV minimum-racemization coupling of nα-9-fluorenylmethyloxycarbonyl amino acids to alkoxy benzyl alcohol type resins
TL;DR: The cesium salts of N α -9-fluorenylmethyloxycarbonyl (Fmoc) amino acids couple smoothly to new chloro derivatives of alkoxy benzyl alcohol resins.