M
Michael S. Lan
Researcher at LSU Health Sciences Center New Orleans
Publications - 98
Citations - 5565
Michael S. Lan is an academic researcher from LSU Health Sciences Center New Orleans. The author has contributed to research in topics: Gene & Antigen. The author has an hindex of 37, co-authored 96 publications receiving 5343 citations. Previous affiliations of Michael S. Lan include Boston Children's Hospital & University of Maryland, Baltimore.
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Specific, major histocompatibility complex-unrestricted recognition of tumor-associated mucins by human cytotoxic T cells
TL;DR: Detailed studies performed with one of the cytotoxic T-cell lines from pancreatic cancer patients show that it recognizes a specific antigen, a large and heavily glycosylated mucin molecule, expressed on pancreatic and breast tumors and tumor cell lines.
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Cloning and sequencing of a human pancreatic tumor mucin cDNA.
TL;DR: The cDNA and deduced amino acid sequence of the pancreatic mucin sequence was over 99% homologous with a mucin cDNA sequence derived from breast tumor mucin, even though the native forms of these molecules are quite distinct in size and degree of glycosylation.
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Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma.
TL;DR: It appears that IA-2 is a new member of the receptor-type PTP family that is expressed in islet and brain tissues that possesses highly conserved regions similar to the catalytic domains found in members of the protein tyrosine phosphatase (PTP) family.
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IA-2, a transmembrane protein of the protein tyrosine phosphatase family, is a major autoantigen in insulin-dependent diabetes mellitus
TL;DR: It is concluded that IA-2 is a major islet cell autoantigen in IDDM, and, together with GAD65, is responsible for much of the reactivity of ICA with pancreatic islets.
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Identification of a second transmembrane protein tyrosine phosphatase, IA-2beta, as an autoantigen in insulin-dependent diabetes mellitus: precursor of the 37-kDa tryptic fragment.
Jia Lu,Qing Li,Hong Xie,Zhi-Jian Chen,Anna E. Borovitskaya,Noel K. Maclaren,Abner Louis Notkins,Michael S. Lan +7 more
TL;DR: It is concluded that IA-2beta and IA- 2 are the precursors of the 37-kDa and 40-k da islet cell autoantigens, respectively, and that both IA-1 andIA-2 are major autoantigen in insulin-dependent diabetes mellitus.