P
P R Larsen
Researcher at Howard Hughes Medical Institute
Publications - 2
Citations - 452
P R Larsen is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Thyroxine deiodinase & Triiodothyronine. The author has an hindex of 2, co-authored 2 publications receiving 443 citations.
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Kinetic evidence suggesting two mechanisms for iodothyronine 5'-deiodination in rat cerebral cortex
TL;DR: Evidence was obtained for the existence of two thiol-dependent 5'-deiodinase entities that predominates in tissue from euthyroid and long-term hypothyroid rats, and one of these follows "ping-pong" kinetics with dithiothreitol as the cosubstrate, and is inhibited by propylthiouracil (PrSUra) and iodoacetate.
Journal ArticleDOI
Cerebral cortex responds rapidly to thyroid hormones
TL;DR: The results indicate that the adult central nervous system can give a very rapid biochemical response to thyroid hormone.