P
Penelope M.S. Clark
Researcher at University of Cambridge
Publications - 57
Citations - 8996
Penelope M.S. Clark is an academic researcher from University of Cambridge. The author has contributed to research in topics: Insulin & Impaired glucose tolerance. The author has an hindex of 26, co-authored 57 publications receiving 8713 citations. Previous affiliations of Penelope M.S. Clark include Queen Elizabeth Hospital Birmingham.
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Journal ArticleDOI
Fetal and infant growth and impaired glucose tolerance at age 64.
C. N. Hales,David J.P. Barker,Penelope M.S. Clark,Lorna Cox,Caroline H.D. Fall,Clive Osmond,P D Winter +6 more
TL;DR: Reduced growth in early life is strongly linked with impaired glucose tolerance and non-insulin dependent diabetes and reduced early growth is also related to a raised plasma concentration of 32-33 split proinsulin, which is interpreted as a sign of beta cell dysfunction.
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Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth
TL;DR: It is concluded that Type 2 diabetes and hypertension have a common origin in sub-optimal development in utero, and that syndrome X should perhaps be re-named “the small-baby syndrome”.
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Understanding Oral Glucose Tolerance: Comparison of Glucose or Insulin Measurements During the Oral Glucose Tolerance Test with Specific Measurements of Insulin Resistance and Insulin Secretion
TL;DR: It is concluded that the oral glucose tolerance test can be used to derive estimates of the relative roles of insulin secretion and insulin resistance in population studies of glucose tolerance.
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Fetal growth and impaired glucose tolerance in men and women
TL;DR: The association between impaired glucose tolerance in adult life and low birthweight previously reported in Hertfordshire (UK) is confirmed and demonstrated in women as well as men, suggesting that the association reflects the long-term effects of reduced growth of the endocrine pancreas and other tissues in utero.
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Fetal and infant growth and cardiovascular risk factors in women.
Caroline H.D. Fall,Clive Osmond,David J.P. Barker,Penelope M.S. Clark,C. N. Hales,Yvonne Stirling,T W Meade +6 more
TL;DR: In women, as in men, reduced fetal growth leads to insulin resistance and the associated disorders: raised blood pressure and high serum triglyceride and low serum high density lipoprotein cholesterol concentrations.