抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

We will review some of the major results in random graphs and some of the more challenging open problems. We will cover algorithmic and structural questions. We will touch on newer models, including those related to the WWW.

Random graphs

A review of the geologic history of the Himalayan-Tibetan orogen suggests that at least 1400 km of north-south shortening has been absorbed by the orogen since the onset of the Indo-Asian collision at about 70 Ma. Significant crustal shortening, which leads to eventual construction of the Cenozoic Tibetan plateau, began more or less synchronously in the Eocene (50–40 Ma) in the Tethyan Himalaya in the south, and in the Kunlun Shan and the Qilian Shan some 1000–1400 km in the north. The Paleozoic and Mesozoic tectonic histories in the Himalayan-Tibetan orogen exerted a strong control over the Cenozoic strain history and strain distribution. The presence of widespread Triassic flysch complex in the Songpan-Ganzi-Hoh Xil and the Qiangtang terranes can be spatially correlated with Cenozoic volcanism and thrusting in central Tibet. The marked difference in seismic properties of the crust and the upper mantle between southern and central Tibet is a manifestation of both Mesozoic and Cenozoic tectonics. The form...

Geologic Evolution of the Himalayan-Tibetan Orogen

N G van Kampen 1981 Amsterdam: North-Holland xiv + 419 pp price Dfl 180 This is a book which, at a lower price, could be expected to become an essential part of the library of every physical scientist concerned with problems involving fluctuations and stochastic processes, as well as those who just enjoy a beautifully written book. It provides an extensive graduate-level introduction which is clear, cautious, interesting and readable.

https://iopscience.iop.org/article/10.1088/0031-9112/34/4/040/pdf

Stochastic Processes in Physics and Chemistry

Convective removal of lower lithosphere beneath the Tibetan Plateau can account for a rapid increase in the mean elevation of the Tibetan Plateau of 1000 m or more in a few million years. Such uplift seems to be required by abrupt tectonic and environmental changes in Asia and the Indian Ocean in late Cenozoic time. The composition of basaltic volcanism in northern Tibet, which apparently began at about 13 Ma, implies melting of lithosphere, not asthenosphere. The most plausible mechanism for rapid heat transfer to the midlithosphere is by convective removal of deeper lithosphere and its replacement by hotter asthenosphere. The initiation of normal faulting in Tibet at about 8 (± 3) Ma suggests that the plateau underwent an appreciable increase in elevation at that time. An increase due solely to the isostatic response to crustal thickening caused by India's penetration into Eurasia should have been slow and could not have triggered normal faulting. Another process, such as removal of relatively cold, dense lower lithosphere, must have caused a supplemental uplift of the surface. Folding and faulting of the Indo-Australian plate south of India, the most prominent oceanic intraplate deformation on Earth, began between about 7.5 and 8 Ma and indicates an increased north-south compressional stress within the Indo-Australian plate. A Tibetan uplift of only 1000 m, if the result of removal of lower lithosphere, should have increased the compressional stress that the plateau applies to India and that resists India's northward movement, from an amount too small to fold oceanic lithosphere, to one sufficient to do so. The climate of the equatorial Indian Ocean and southern Asia changed at about 6–9 Ma: monsoonal winds apparently strengthened, northern Pakistan became more arid, but weathering of rock in the eastern Himalaya apparently increased. Because of its high altitude and lateral extent, the Tibetan Plateau provides a heat source at midlatitudes that should oppose classical (symmetric) Hadley circulation between the equator and temperate latitudes and that should help to drive an essentially opposite circulation characteristic of summer monsoons. For the simple case of axisymmetric heating (no dependence on longitude) of an atmosphere without dissipation, theoretical analyses by Hou, Lindzen, and Plumb show that an axisymmetric heat source displaced from the equator can drive a much stronger meridianal (monsoonlike) circulation than such a source centered on the equator, but only if heating exceeds a threshold whose level increases with the latitude of the heat source. Because heating of the atmosphere over Tibet should increase monotonically with elevation of the plateau, a modest uplift (1000–2500 m) of Tibet, already of substantial extent and height, might have been sufficient to exceed a threshold necessary for a strong monsoon. The virtual simultaneity of these phenomena suggests that uplift was rapid: approximately 1000 m to 2500 m in a few million years. Moreover, nearly simultaneously with the late Miocene strengthening of the monsoon, the calcite compensation depth in the oceans dropped, plants using the relatively efficient C4 pathway for photosynthesis evolved rapidly, and atmospheric CO2 seems to have decreased, suggesting causal relationships and positive feedbacks among these phenomena. Both a supplemental uplift of the Himalaya, the southern edge of Tibet, and a strengthened monsoon may have accelerated erosion and weathering of silicate rock in the Himalaya that, in turn, enhanced extraction of CO2 from the atmosphere. Thus these correlations offer some support for links between plateau uplift, a downdrawing of CO2 from the atmosphere, and global climate change, as proposed by Raymo, Ruddiman, and Froehlich. Mantle dynamics beneath mountain belts not only may profoundly affect tectonic processes near and far from the belts, but might also play an important role in altering regional and global climates.

Mantle dynamics, uplift of the Tibetan Plateau, and the Indian Monsoon

Scaling in fracture systems has become an active field of research in the last 25 years motivated by practical applications in hazardous waste disposal, hy- drocarbon reservoir management, and earthquake haz- ard assessment. Relevant publications are therefore spread widely through the literature. Although it is rec- ognized that some fracture systems are best described by scale-limited laws (lognormal, exponential), it is now recognized that power laws and fractal geometry provide widely applicable descriptive tools for fracture system characterization. A key argument for power law and fractal scaling is the absence of characteristic length scales in the fracture growth process. All power law and fractal characteristics in nature must have upper and lower bounds. This topic has been largely neglected, but recent studies emphasize the importance of layering on all scales in limiting the scaling characteristics of natural fracture systems. The determination of power law expo- nents and fractal dimensions from observations, al- though outwardly simple, is problematic, and uncritical use of analysis techniques has resulted in inaccurate and even meaningless exponents. We review these tech- niques and suggest guidelines for the accurate and ob- jective estimation of exponents and fractal dimensions. Syntheses of length, displacement, aperture power law exponents, and fractal dimensions are found, after crit- ical appraisal of published studies, to show a wide vari- ation, frequently spanning the theoretically possible range. Extrapolations from one dimension to two and from two dimensions to three are found to be nontrivial, and simple laws must be used with caution. Directions for future research include improved techniques for gathering data sets over great scale ranges and more rigorous application of existing analysis methods. More data are needed on joints and veins to illuminate the differences between different fracture modes. The phys- ical causes of power law scaling and variation in expo- nents and fractal dimensions are still poorly understood.

/pdf/scaling-of-fracture-systems-in-geological-media-1uq6op1ap8.pdf

Scaling of fracture systems in geological media

Experiments on shortening of a 4-layer model of the continental lithosphere

Lateral extrusion encompasses extensional collapse (gravitational spreading away from a topographic high in an orogenic belt) and tectonic escape (plane strain horizontal motion of wedges driven by forces applied to their boundaries). In the Eastern Alps it resulted from (1) an overall northerly compression (Apulia against Eurasia), (2) a strong foreland (Bohemian massif), (3) lack of constraint along a lateral boundary (Carpathian region), and (4) a previously thickened, gravitationally unstable, thermally weakened crust (Eastern Alpine orogenic belt). Six indentation experiments reproduce lateral extrusion at lithospheric scale. The models have two to four lithospheric layers, with a Mohr/Coulomb rheology for the upper and a viscous rheology for the lower crust. The lithosphere rests upon a low-viscosity asthenosphere. A broad indenter, a narrow deformable area, and a weakly constrained eastern margin fullfill as closely as possible conditions in the Eastern Alps. Indentation produces both thickening in front of the indenter and escape of triangular wedges. Lateral variations in crustal thickness become attenuated by gravitational spreading. The overall fault pattern includes domains of reverse, strike-slip, oblique normal, and pure normal faults. Strike-slip faults in conjugate sets develop serially. The narrow width of the deformable area and the strength of the foreland determine the angles between the sets. Gravitational spreading produces a rhombohedral pattern of oblique and pure normal faults along the unconstrained margin. Opposite the unconstrained margin, the indenter front shows thrusts and folds intersecting with the conjugate strike-slip sets. A triangular indenter favors spreading. High velocity of indentation favors escape. High confinement limits lateral motion, inhibits spreading, and favors thickening. Lateral extrusion in the Eastern Alps is best modeled by (1) a weak lateral confinement, (2) a broad and straight indenter, (3) a narrow width of the deformable area, and (4) a rigid foreland. Crustal thickening, lateral escape, and gravitational spreading all contribute to the overall deformation.

Lateral extrusion in the eastern Alps, Part 1: Boundary conditions and experiments scaled for gravity

We present a theoretical and numerical study of the connectivity of fault networks following power law fault length distributions, n(l) ∼ αl−a, as expected for natural fault networks. Different regimes of connectivity are identified depending on a. For a > 3, faults smaller than the system size rule the network connectivity and classical laws of percolation theory apply. On the opposite, for a < 1, the connectivity is ruled by the largest fault in the system. For 1 < a < 3, both small and large faults control the connectivity in a ratio which depends on a. The geometrical properties of the fault network and of its connected parts (density, scaling properties) are established at the percolation threshold. Finally, implications are discussed in the case of fault networks with constant density. In particular, we predict the existence of a critical scale at which fault networks are always connected, whatever a smaller than 3, and whatever their fault density.

https://agupubs.onlinelibrary.wiley.com/doi/pdf/10.1029/96WR00433

Philippe Davy

Papers

Scaling of fracture systems in geological media

Experiments on shortening of a 4-layer model of the continental lithosphere

Lateral extrusion in the eastern Alps, Part 1: Boundary conditions and experiments scaled for gravity

Connectivity of random fault networks following a power law fault length distribution

The Namche Barwa syntaxis: evidence for exhumation related to compressional crustal folding