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Robert L. Giles
Researcher at University of Utah
Publications - 11
Citations - 245
Robert L. Giles is an academic researcher from University of Utah. The author has contributed to research in topics: Nucleophile & Moiety. The author has an hindex of 5, co-authored 11 publications receiving 233 citations.
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Addition-hydroamination reactions of propargyl cyanamides: rapid access to highly substituted 2-aminoimidazoles.
TL;DR: The synthesis of the propargyl cyanamide precursors through a three-component coupling enables the preparation of this important heterocyclic core structure in just three steps.
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2-Aminoimidazoles from Leucetta Sponges: Synthesis and Biology of an Important Pharmacophore
TL;DR: This review will focus on the ability of the 2-aminoimidazole to occupy a unique subset of chemical space which makes it an ideal pharmacophore for the development of small molecule collections for discovery based research.
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Total Synthesis of Epothilones B and D: Stannane Equivalents for β-Keto Ester Dianions
TL;DR: Key reactions in the synthesis include a stereoselective SmI(2) reduction of a beta-hydroxy ketone and a critical opening of a valerolactone with aniline which required extensive investigation.
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Synthesis of 2-thio- and 2-oxoimidazoles via cascade addition-cycloisomerization reactions of propargylcyanamides.
TL;DR: A methodology to generate 2-thio- and 2-oxoimidazoles through an addition-cyclization-isomerization reaction of propargylcyanamides with thiol and alcohol nucleophiles in good to excellent yields is described.
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Catalytic asymmetric Diels–Alder reactions of α-thioacrylates for the preparation of norbornenone
TL;DR: In this article, the asymmetric Diels-Alder cycloaddition of α-thioacrylates with cyclopentadiene was used to give the cycloadducts in up to 92% yield, 88% de and >95% ee for the endo product.