S
S. Kirk-Bell
Researcher at University of Sussex
Publications - 4
Citations - 817
S. Kirk-Bell is an academic researcher from University of Sussex. The author has contributed to research in topics: Nucleotide excision repair & Xeroderma pigmentosum. The author has an hindex of 2, co-authored 4 publications receiving 812 citations.
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Journal ArticleDOI
Xeroderma pigmentosum cells with normal levels of excision repair have a defect in DNA synthesis after UV-irradiation.
Alan R. Lehmann,S. Kirk-Bell,Colin F. Arlett,M. C. Paterson,P. H. M. Lohman,E. A. de Weerd-Kastelein,Dirk Bootsma +6 more
TL;DR: Two cell lines from classes of xeroderma pigmentosum that are defective in excision-repair show intermediate effects, with regard to both the time taken to convert newly synthesized DNA to high molecular weight and the inhibition of this process by caffeine.
Journal Article
Repair of ultraviolet light damage in a variety of human fibroblast cell strains.
Alan R. Lehmann,S. Kirk-Bell,Colin F. Arlett,Susan A. Harcourt,E. A. de Weerd-Kastelein,W. Keijzer,P Hall-Smith +6 more
TL;DR: The defect in postreplication repair previously found in XP variants (excision-proficient XP's) has now been observed in a total of five XP variants and a less severe defect has been found in excision-defective XP's in Complementation Groups A, B, C, and D.
Book ChapterDOI
Postreplication Repair in Human Fibroblasts
TL;DR: Postreplication repair is defective in fibroblasts from all the xeroderma pigmentosum complementation groups with the exception of group E, the defect being most pronounced in the excision-proficient XP variants.
Xeroderma Pigmentosum Cells with Norm Have a Defect in DNA Synthesis after UV
TL;DR: It is found that cells cultured from most patients suffer from the sunlight-sensitive hereditary disorder xero- derma pigmentosum have an abnormal- ity in the manner in which DNA is synthesized after UV- irradiation.